The synergistic effect of Mig-6 and Pten ablation on endometrial cancer development and progression.
The synergistic effect of Mig-6 and Pten ablation on endometrial cancer development and progression.
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DOI：
10.1038/onc.2010.126
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发表时间：
2010-07-01
期刊：
影响因子：
8
通讯作者：
Jeong, J-W
中科院分区：
文献类型：
--
作者：
Kim, T. H.;Franco, H. L.;Jung, S. Y.;Qin, J.;Broaddus, R. R.;Lydon, J. P.;Jeong, J-W
Ablation of Mig-6 in the murine uterus leads to the development of endometrial hyperplasia and estrogen-induced endometrial cancer. An additional endometrial cancer mouse model is generated by ablation of Pten (either as heterozygotes or by conditional uterine ablation). To determine the interplay between Mig-6 and the PTEN/PI3K signaling pathway during endometrial tumorigenesis, we have generated mice with Mig-6 and Pten conditionally ablated in progesterone receptor positive cells (PRcre/+Mig-6f/fPtenf/f ; Mig-6d/dPtend/d). The ablation of both Mig-6 and Pten dramatically accelerated the development of endometrial cancer compared to single ablation of either gene. The epithelium of Mig-6d/dPtend/d mice showed a significant decrease in the number of apoptotic cells compared to Ptend/d mice. The expression of the estrogen-induced apoptotic inhibitors Birc1 was significantly increased in the Mig-6d/dPtend/d mice. We identified ERK2 as a MIG-6 interacting protein by co-immunoprecipitation and demonstrated that the level of ERK2 phosphorylation was increased upon Mig-6 ablation either singly or in combination with Pten ablation. These results suggest that Mig-6 exerts a tumor suppressor function in endometrial cancer by promoting epithelial cell apoptosis through the down-regulation of the estrogen-induced apoptosis inhibitors Birc1 and the inhibition of ERK2 phosphorylation.
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影响因子：
7.4
作者：
Jung, Sung Yun;Li, Yehua;Qin, Jun
通讯作者：
Qin, Jun
影响因子：
4.8
作者：
Davoodi, J;Lin, L;MacKenzie, AE
通讯作者：
MacKenzie, AE
影响因子：
--
作者：
Jung, SY;Malovannaya, A;Qin, J
通讯作者：
Qin, J
影响因子：
8
作者：
Anastasi, S;Sala, G;Segatto, O
通讯作者：
Segatto, O
DOI：
10.1073/pnas.0903632106
发表时间：
2009-05-26
影响因子：
11.1
作者：
Jeong, Jae-Wook;Lee, Hee Sun;DeMayo, Francesco J.
通讯作者：
DeMayo, Francesco J.