Cancer incidence in pet dogs: Findings of the animal tumor registry of Genoa, Italy
Cancer incidence in pet dogs: Findings of the animal tumor registry of Genoa, Italy
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DOI：
10.1111/j.1939-1676.2008.0133.x
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发表时间：
2008-07-01
影响因子：
2.6
通讯作者：
Bocchini, V.
中科院分区：
文献类型：
--
作者：
Merlo, D. F.;Rossi, L.;Bocchini, V.
背景资料：在一些欧洲和北美兽医癌症登记处与不同的方法和变量的参考populations.Objectives：动物肿瘤登记处（ATR）的热那亚，意大利，成立于1985年，估计自发性肿瘤的发生在狗的目的已经估计了自发性肿瘤的发生。研究方法：1985年至2002年期间，从热那亚市当地兽医处收到了6743份肿瘤活检标本。3303（48.9%）活检标本样本被诊断为癌症，并根据国际疾病统计分类（ICD-9）进行编码。所有癌症的发病率为99.3/100，000狗年（95% CI：93.6-105。1)雄性犬为272.1（95% CI：260.7-283.6）。乳腺癌的发病率最高（IR = 191.8，95% CI：182.2-201.4）和非霍奇金淋巴瘤（IR 22.9，95% CI：19.7-26.5）在母犬和非霍奇金淋巴瘤中（IR = 19.9，95% CI：17.4-22.7）和皮肤癌（IR 19.1，95% CI：16.6-21.8）。所有癌症IR均随年龄增加，范围为23.7（95% CI：18.4-30.1）和763.2（95% CI：700.4-830.1），在16.5结论：本研究总结了意大利热那亚ATR在1985年至2002年期间所做的工作。雌性犬的所有癌症发病率均比雄性犬高3倍，这一差异可通过在母犬中观察到的高乳腺癌发病率来解释。由于需要活检标本来进行癌症诊断，因此在研究人群中，内脏癌症（如呼吸道和消化道癌症）的癌症发生率可能被低估。
Background: The occurrence of spontaneous tumors in pet animals has been estimated in a few European and North American veterinary cancer registries with dissimilar methodologies and variable reference populations.Objectives: The Animal Tumor Registry (ATR) of Genoa, Italy, was established in 1985 with the aim of estimating the occurrence of spontaneous tumors in dogs. Methods: Six thousand seven hundred and forty-three tumor biopsy specimens were received from local veterinarians in the Municipality of Genoa between 1985 and 2002. Three thousand and three hundred and three (48.9%) biopsy specimen samples were diagnosed as cancer and were coded according to the International Statistical Classification of Diseases (ICD-9).Results: Mammary cancer was the most frequently diagnosed cancer in female dogs, accounting for 70% of all cancer cases. Incidence of all cancers was 99.3 per 100,000 dog-years (95% CI: 93.6-105. 1) in male dogs and 272.1 (95% CI: 260.7-283.6) in female dogs. The highest incidence rates were detected for mammary cancer (IR = 191.8, 95% CI: 182.2-201.4) and for non-Hodgkin's lymphoma (IR 22.9, 95% CI: 19.7-26.5) in bitches and for non-Hodgkin's lymphoma (IR = 19.9, 95% CI: 17.4-22.7) and skin cancer (IR 19.1, 95% CI: 16.6-21.8) in male dogs. All cancer IR increased with age ranging between 23.7 (95% CI: 18.4-30.1) and 763.2 (95% CI: 700.4-830.1) in bitches and between 16.5 (95% CI: 12.8-21.1) and 237.6 (95% CI: 209.1-269.0) in maledogs aged 9-11 years.Conclusion: This study summarizes the work done by the ATR of Genoa, Italy, between 1985 and 2002. All cancer incidence was 3 times higher in female than in male dogs, a difference explained by the high rate of mammary cancer observed in bitches. Because a biopsy specimen was required to make a cancer diagnosis, cancer rates for internal organs cancers, such as respiratory and digestive tract cancers may have been underestimated in the study population.