Periodontitis may increase the risk of peripheral arterial disease
Periodontitis may increase the risk of peripheral arterial disease
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DOI：
10.1016/j.ejvs.2007.08.016
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发表时间：
2008-02-01
影响因子：
5.7
通讯作者：
Ishikawa, I.
中科院分区：
文献类型：
--
作者：
Chen, Y. -W.;Umeda, M.;Ishikawa, I.
目标。这项病例对照研究的目的是评估牙周炎是否与外周动脉疾病(PAD)相关。研究对象和方法。25例诊断为主动脉-髂动脉和/或股静脉窝闭塞症的患者和32例健康体检者进入本研究。采用聚合酶链式反应(PCR)技术检测远端搭桥吻合口标本中的牙龈卟啉单胞菌、齿密螺旋体、伴生放线杆菌、中间普氏杆菌、巨细胞病毒、肺炎衣原体和幽门螺杆菌。对牙周状况进行评估，并测定血清中4种细菌的抗体滴度。在25例动脉粥样硬化标本中检出牙周病原菌13例(52%)。1125例(4%)标本中检出巨细胞病毒或肺炎衣原体，未检出幽门螺杆菌。Fontaine III级和IV级牙周炎患者的牙龈假单胞菌阳性率明显高于Fontaine II级患者(57.1%vs22.2%，P=0.09)。在调整了年龄、性别、糖尿病和吸烟因素后，牙周炎患PAD的风险增加了5倍(OR 5.45)。有初步迹象表明，牙周炎与血清IL-6和TNF-α浓度升高有关。这项研究表明，牙周炎可能与PAD风险增加有关。这种关联可能是由于牙周炎患者血清炎性细胞因子浓度升高所致。(C)2007年由爱思唯尔有限公司代表欧洲血管外科学会出版。
Objectives. The aim of this case control study was to evaluate whether periodontitis was associated with peripheral arterial disease (PAD). Subjects andMethods. Twenty-five patients diagnosed with aorto-iliac and/or femoro-popliteal occlusive disease and thirty-two generally healthy control subjects were enrolled in this study. Polymerase chain reaction (PCR) was used to identify Porphyromonas gingivalis, Treponema denticola, Actinobacillus actinomycetemcomitans, Prevotella intermedia, Cytomegalovirus (CMV), Chlamydia pneumoniae, and Helicobacter pylori in tissue specimens taken from the anastomotic site of distal bypasses. Periodontal status was evaluated; serum IgG titres against the four listed bacteria were measured.Results. Periodontopathic bacteria were detected in 13/25 (52%) atherosclerotic specimens. CMV or C. pneumoniae was detected in 1125 (4%) specimens; H. pylori was not detected from any of these specimens. Fontaine grade III or IV patients showed higher detection frequency of P. gingivalis than Fontaine grade II patients (57.1% vs 22.2%, P = 0.09). After adjusting for age, gender, diabetes and smoking, periodontitis increased 5-fold the risk of having PAD (OR 5.45). There were preliminary indications that periodontitis was associated with increased serum IL-6 and TNF-alpha concentrations.Conclusions. This study suggests that periodontitis may be associated with an increased risk of PAD. This association could result from the increased concentration of serum inflammatory cytokines in those with periodontitis. (c) 2007 Published by Elsevier Ltd on behalf of European Society for Vascular Surgery.