Nuclear factor I/B is an oncogene in small cell lung cancer
Nuclear factor I/B is an oncogene in small cell lung cancer
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DOI：
10.1101/gad.2046711
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发表时间：
2011-07-15
影响因子：
10.5
通讯作者：
Jacks, Tyler
中科院分区：
文献类型：
--
作者：
Dooley, Alison L.;Winslow, Monte M.;Jacks, Tyler
小细胞肺癌（SCLC）是一种侵袭性癌症，通常在转移后诊断。尽管需要更好地了解这种疾病，但SCLC在分子和基因组水平上的特征仍然很差。使用基因工程小鼠模型的SCLC驱动的条件性缺失Trp 53和Rb 1在肺中，我们确定了几个频繁的，高幅度的局灶性DNA拷贝数的改变在SCLC。我们在小鼠SCLC模型和人SCLC中发现了一种新的致癌转录因子核因子I/B（Nfib）的扩增。功能研究表明，NFIB在转化过程中调节细胞活力和增殖。
Small cell lung cancer (SCLC) is an aggressive cancer often diagnosed after it has metastasized. Despite the need to better understand this disease, SCLC remains poorly characterized at the molecular and genomic levels. Using a genetically engineered mouse model of SCLC driven by conditional deletion of Trp53 and Rb1 in the lung, we identified several frequent, high-magnitude focal DNA copy number alterations in SCLC. We uncovered amplification of a novel, oncogenic transcription factor, Nuclear factor I/B (Nfib), in the mouse SCLC model and in human SCLC. Functional studies indicate that NFIB regulates cell viability and proliferation during transformation.