Changes in Circulating Satiety Hormones in Obese Children: A Randomized Controlled Physical Activity-Based Intervention Study
Changes in Circulating Satiety Hormones in Obese Children: A Randomized Controlled Physical Activity-Based Intervention Study
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DOI：
10.1038/oby.2009.498
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发表时间：
2010-09-01
期刊：
影响因子：
6.9
通讯作者：
Funanage, Vicky L.
中科院分区：
文献类型：
--
作者：
Balagopal, Prabhakaran (Babu);Gidding, Samuel S.;Funanage, Vicky L.
本研究的目的是在儿童中检查：（i）肥胖相关的饱腹感因素（如瘦素，生长激素释放肽和肥胖抑制素）的变化;（ii）饱腹感因素和心脏代谢危险因素之间的联系;（iii）基于身体活动的生活方式干预对肥胖者这些饱腹感因素水平的影响。我们共研究了21名青少年（BMI百分位数，15名肥胖者为99.0 +/- 0.6，6名消瘦者为56.2 +/- 1.1）。肥胖受试者接受了为期3个月的随机对照的基于体力活动的生活方式干预。瘦素、可溶性瘦素受体（sOB-R）、生长激素释放肽和肥胖抑制素水平被确定为主要结果指标。还测定了其他心脏代谢疾病的标志物，如炎症和胰岛素抵抗。采用双能X线吸收法测定身体成分。肥胖儿童的ghrelin、obestatin和sOB-R水平显著低于瘦儿童，而leptin水平显著高于瘦儿童（均P < 0.05）。虽然干预导致肥胖抑制素的净增加（P < 0.01），而ghrelin水平没有变化，但ghrelin和肥胖抑制素之间的平衡（ghrelin与肥胖抑制素的比率，G/O）降低（P < 0.02）。干预降低了瘦素水平，增加了sOB-R水平（P < 0.01）。饱腹感因素和其他心脏代谢危险因素之间也有显著的相关性。总的来说，饱腹感因素水平的改变在肥胖的临床过程的早期是明显的，但是基于身体活动的生活方式干预要么阻止了它们的持续增加，要么使它们的水平正常化。这些有益的作用似乎有助于维持体重和降低心血管风险。
The aims of this study are to examine in children: (i) obesity-related alterations in satiety factors such as leptin, ghrelin, and obestatin; (ii) the link between satiety factors and cardiometabolic risk factors; and (iii) the impact of a physical activity-based lifestyle intervention on the levels of these satiety factors in the obese. We studied a total of 21 adolescents (BMI percentile, 99.0 +/- 0.6 for 15 obese and 56.2 +/- 1.1 for 6 lean). The obese subjects underwent a 3-month randomized controlled physical activity-based lifestyle intervention. Leptin, soluble leptin receptor (sOB-R), ghrelin, and obestatin levels were determined as the primary outcome measures. Other markers of cardiometabolic disease such as inflammation and insulin resistance were also determined. Body composition was measured by dual-energy X-ray absorptiometry. The concentrations of ghrelin, obestatin, and sOB-R were significantly lower in the obese children compared to the lean controls, whereas that of leptin was higher (all P < 0.05). Although intervention led to a net increase in obestatin (P < 0.01) and no change in ghrelin levels, the balance between ghrelin and obestatin (ratio of ghrelin to obestatin, G/O) decreased (P < 0.02). Intervention reduced leptin and increased sOB-R (P < 0.01 for both). Significant associations between satiety factors and other cardiometabolic risk factors were also observed. Taken together, alterations in the levels of satiety factors are evident early in the clinical course of obesity, but physical activity-based lifestyle intervention either prevented their continued increase or normalized their levels. These beneficial effects appear to aid in the maintenance of body weight and reduction in cardiovascular risk.