Cardiac metastasis from colon cancer effectively treated with 5-fluorouracil, leucovorin, and oxaliplatin (modified FOLFOX6) plus panitumumab: a case report.
Cardiac metastasis from colon cancer effectively treated with 5-fluorouracil, leucovorin, and oxaliplatin (modified FOLFOX6) plus panitumumab: a case report.
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DOI：
10.1186/s12885-017-3147-2
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发表时间：
2017-02-23
期刊：
影响因子：
3.8
通讯作者：
Takehara T
中科院分区：
文献类型：
--
作者：
Tsujii Y;Hayashi Y;Maekawa A;Fujinaga T;Nagai K;Yoshii S;Sakatani A;Hiyama S;Shinzaki S;Iijima H;Takehara T
结直肠癌的心脏转移是罕见的。几乎没有证据支持化疗的有效性，转移性心脏肿瘤的标准治疗尚未建立。一位76岁的妇女提出了一个右心室肿瘤是偶然发现筛选心脏超声。最初的计算机断层扫描（CT）显示心脏肿瘤，大小约为40 mm，和多个肺结节。血清肿瘤标志物CEA和CA 19 -9水平异常升高。通过结肠镜检查发现疑似原发性肿瘤，横结肠高分化腺癌伴野生型KRAS，并开始接受5-氟尿嘧啶、亚叶酸和奥沙利铂（改良FOLFOX 6）联合帕尼单抗治疗。治疗4个疗程后，CT扫描显示心脏肿瘤明显缩小，肺结节缩小。血清CEA、CA 19 -9水平也明显降低。在10个月的治疗期间进行了12个疗程的化疗后，患者继续显示出部分反应，并且她在15个疗程的治疗中继续保持无症状。据我们所知，这是第一次报告的联合治疗的疗效，使用细胞毒性和分子靶向药物对心脏转移的结肠癌。
Cardiac metastasis from colorectal cancer is rare. There is little evidence supporting the effectiveness of chemotherapy, and standard therapy for metastatic cardiac tumors has not been established. A 76-year-old woman presented with a right ventricle tumor that was detected incidentally on screening cardiac ultrasonography. The initial computed tomography (CT) scan showed the cardiac tumor, which was approximately 40 mm in size, and multiple pulmonary nodules. Serum levels of tumor markers CEA and CA19-9 were elevated aberrantly. The suspected primary tumor, a well-differentiated adenocarcinoma of the transverse colon with wild-type KRAS was found by colonoscopy, and treatment with 5-fluorouracil, leucovorin, and oxaliplatin (modified FOLFOX6) plus panitumumab was initiated. After 4 courses of the therapy, a CT scan showed that the cardiac tumor size had markedly decreased and the pulmonary nodules had diminished. The serum levels of CEA and CA19-9 were also markedly decreased. After 12 courses of chemotherapy during 10 months of treatment, the patient continued to show a partial response, and she remained asymptomatic with continuation of the treatment through 15 courses. To the best of our knowledge, this is the first report of the efficacy of combination therapy using cytotoxic and molecular targeted agents against cardiac metastasis from colon cancer.