Complementary roles for the amygdala and hippocampus during different phases of appetitive information processing
Complementary roles for the amygdala and hippocampus during different phases of appetitive information processing
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DOI：
10.1016/j.nlm.2005.06.001
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发表时间：
2005-09-01
影响因子：
2.7
通讯作者：
Holahan, MR
中科院分区：
文献类型：
--
作者：
Holahan, MR
从啮齿动物记忆储存模型中收集的证据表明，快速学习涉及多个大脑区域，每个区域都可能参与信息处理的不同组成部分。本研究采用一次性食欲条件反射任务，在信息处理的不同阶段暂时性失活杏仁核和海马，以探讨这两个区域如何参与食欲记忆的储存。将雄性Long Evans大鼠长期植入杏仁核或背侧海马并剥夺食物。大鼠接受放射状迷宫条件线索偏好任务训练，其中训练在一个40分钟的会话中进行，测试在24小时后进行。杏仁核或海马分别与蝇蕈醇（50纳克/μ l）注射之前或之后立即培训，或测试前立即灭活。注射生理盐水的大鼠表现出一种条件性偏好，即在先前含有食物的手臂上花费的时间比在不含食物的手臂上花费的时间更多。在训练或测试前将蝇蕈醇注射到杏仁核中可以阻断条件性偏爱。在训练后立即将蝇蕈醇注射到海马中阻断了条件性偏好。这些结果表明，记忆的处理可能需要来自不同大脑系统的多个贡献，至少短期（24小时）存储。来自每个系统的结果输出可以收敛于类似的下游目标以影响行为。(c)2005年爱思唯尔公司All rights reserved.
Evidence collected from rodent models of memory storage suggests that rapid forms of learning engage the involvement of multiple brain regions each of which may participate in a different component of information processing. The present study used temporary inactivation of the amygdala and hippocampus during different phases of information processing on a one-trial appetitive-conditioning task to examine how these two regions might participate in the storage of appetitive memories. Male Long Evans rats were chronically implanted into the amygdala or dorsal hippocampus and food deprived. Rats were trained on a radial maze conditioned cue preference task where training occurred in one 40-min session and testing took place 24 h later. The amygdala or hippocampus was inactivated separately with muscimol (50 ng/mu l) injected immediately before or after training, or immediately before testing. Saline-injected rats displayed a conditioned preference by spending more time in the arm that previously contained food than in the arm that did not contain food. Muscimol injected into the amygdala before training or testing blocked the conditioned preference. Muscimol injected into the hippocampus immediately after training blocked the conditioned preference. These results suggest that the processing of memories may require multiple contributions from separate brain systems for at least short-term (24 h) storage. The resulting output from each system may converge on a similar downstream target to influence behavior. (c) 2005 Elsevier Inc. All rights reserved.