Time distortions in Alzheimer's disease: a systematic review and theoretical integration.
Time distortions in Alzheimer's disease: a systematic review and theoretical integration.
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DOI：
10.1038/npjamd.2016.16
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发表时间：
2016
影响因子：
5
通讯作者：
Kapogiannis D
中科院分区：
文献类型：
--
作者：
El Haj M;Kapogiannis D
时间感知是人类大脑的一项重要功能，但在阿尔茨海默病 (AD) 中，该功能会受到损害。在这里，我们回顾了 AD 中时间扭曲的实证研究结果，并提供了一个理论框架，整合了 AD 中的时间和记忆扭曲并解释了它们的双向调制。该综述基于对 PubMed 和 PsycInfo 数据库进行的文献调查。根据我们的理论框架，时间扭曲可能会导致精神上投射自己的时间能力下降（即精神时间旅行），从而可能导致 AD 中的情景记忆受损。相反，AD 中的情景记忆受损可能会导致丧失检索时间信息的能力和/或在主观时间中投射自己的能力。 AD 中时间扭曲和记忆力下降之间的关系可共同归因于海马体的参与，因为该大脑区域支持时间感知和记忆，并且优先成为 AD 神经病理过程的目标。讨论了时间扭曲的临床影响并提出了未来研究的方向。
Time perception is an essential function of the human brain, which is compromised in Alzheimer’s disease (AD). Here, we review empirical findings on time distortions in AD and provide a theoretical framework that integrates time and memory distortions in AD and explains their bidirectional modulation. The review was based on a literature survey performed on the PubMed and PsycInfo databases. According to our theoretical framework, time distortions may induce decline in the ability to mentally project oneself in time (i.e., mental time travel), and consequently may contribute to an episodic memory compromise in AD. Conversely, episodic memory compromise in AD may result in a loss of the ability to retrieve information about time and/or the ability to project oneself in subjective time. The relationship between time distortions and memory decline in AD can be jointly attributed to hippocampus involvement, as this brain area supports both time perception and memory and is preferentially targeted by the neuropathological processes of AD. Clinical implications of time distortions are discussed and directions for future research are suggested.