Measured accuracy and precision in quantitative SPECT imaging with iodine-123
Measured accuracy and precision in quantitative SPECT imaging with iodine-123
复制标题
使用碘 123 进行定量 SPECT 成像的测量准确度和精密度
DOI：
10.1109/nssmic.1994.474613
复制
发表时间：
1994
期刊：
影响因子：
--
通讯作者：
R. Coleman
中科院分区：
文献类型：
--
作者：
D. Gilland;R. Jaszczak;J. Bowsher;K. Greer;R. Coleman
这项研究使用实验体模数据评估了/sup 123/i SPECT体积和活动定量的准确性和精密度。考虑了两种重建方法。将二维Metz预滤波和单次迭代张氏衰减补偿的滤波反投影(FB)方法与采用高斯后滤波并将三维发散探测器的响应和衰减引入检测核的迭代ML-EM方法进行了比较。这两种方法都在一系列分辨率和噪声特性上进行了检查。采集了21个SPECT数据集的圆柱形体模，其中包含大小为21.4、12.0和5.7ml的球体，在均匀的背景下(摄取比为5：1)填充了高纯度/sup 123/i。用两种方法重建每个数据集，并使用半自动方法从重建中获得球体体积和活度测量，该半自动方法基于增加的/SUP123/I浓度区域中的强度梯度来定义感兴趣区域。21个测量值的平均值和标准差分别提供了准确度和精密度指标。对于21.4ml的球体，任一种重建方法测量的体积都准确到真实体积的5%以内，标准偏差约为真实体积的8%。对于12.0ml的球体，与FB法相比，迭代法测得的体积在相同精度下的标准偏差明显较小。由于空间分辨率的影响，两种方法都低估了球体的活度。该5.7毫升球体一般低于这些方法的体积和活性定量的大小限制。
This study evaluated /sup 123/I SPECT volume and activity quantitation in terms of accuracy and precision using experimental phantom data. Two reconstruction methods were considered. The filtered backprojection (FB) method with 2D Metz pre-filtering and single iteration Chang attenuation compensation was compared with an iterative ML-EM method that used Gaussian post-filtering and incorporated the 3D divergent detector response and attenuation in the detection kernel. Both methods were examined over a range of resolution and noise characteristics. An ensemble of 21 SPECT data sets were acquired of a cylindrical phantom that contained spheres of size 21.4, 12.0, and 5.7 ml, filled with high purity /sup 123/I in a uniform background (5:1 uptake ratio). Each data set was reconstructed by both methods, and sphere volume and activity measurements were obtained from the reconstructions using a semi-automatic method that defines the region-of-interest based on the intensity gradient in the area of increased /sup 123/I concentration. The mean and standard deviation of the 21 measurements provided accuracy and precision indices, respectively. For the 21.4 ml sphere, the measured volume with either reconstruction method was accurate to within 5% of the true volume with a standard deviation of approximately 8% of the true volume. For the 12.0 ml sphere the measured volume with the iterative method exhibited substantially smaller standard deviation for equal accuracy compared with the FB method. Sphere activity was underestimated with both methods due to spatial resolution effects. The 5.7 ml sphere was generally below the size limit for volume and activity quantitation by these methods.<<ETX>>
具有强度级信息的相对分段连续图像的同时重建、分割和边缘增强。
影响因子：
3.8
作者：
Liang,Z;Jaszczak,R;Coleman,R;Johnson,V
通讯作者：
Johnson,V
使用散射光子补偿改进 SPECT 量化。
DOI：
--
发表时间：
1984
期刊：
Journal of nuclear medicine : official publication, Society of Nuclear Medicine
影响因子：
--
作者：
Jaszczak,RJ;Greer,KL;FloydJr,CE;Harris,CC;Coleman,RE
通讯作者：
Coleman,RE
使用碘 123 SPECT 进行体积和活性定量。
DOI：
--
发表时间：
1994
期刊：
Journal of nuclear medicine : official publication, Society of Nuclear Medicine
影响因子：
--
作者：
Gilland,DR;Jaszczak,RJ;Turkington,TG;Greer,KL;Coleman,RE
通讯作者：
Coleman,RE