A STUDY OF ACUTE-PHASE REACTANT PROTEINS IN INDONESIAN PATIENTS WITH PULMONARY TUBERCULOSIS
A STUDY OF ACUTE-PHASE REACTANT PROTEINS IN INDONESIAN PATIENTS WITH PULMONARY TUBERCULOSIS
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DOI：
10.1016/0041-3879(84)90027-8
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发表时间：
1984-01-01
期刊：
影响因子：
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通讯作者：
SETIABUDI, I
中科院分区：
文献类型：
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作者：
GRANGE, JM;KARDJITO, T;SETIABUDI, I
用激光散射比浊法测定了107名东爪哇涂片阳性肺结核患者和144名健康受试者血清中8种急性期反应物（α 1-抗胰蛋白酶、α 2-巨球蛋白、转铁蛋白、α 1-酸性糖蛋白、C-反应蛋白、血浆铜蓝蛋白、触珠蛋白和补体第三组分[C3]）和IgG、IgM和伊加的水平。这些水平与临床，血液学和放射学特征，结核分枝杆菌抗体水平和结核菌素皮肤试验在不同时间读取的直径相关。肺结核患者除转铁蛋白水平降低外，其他急性期反应物水平均显著升高。计算了健康和疾病中各种急性期反应物之间的相关性。通常，疾病中的相关性低于健康中的相关性，除了C3和α 1-抗胰蛋白酶和血浆铜蓝蛋白水平之间的显著增加的相关性。某些急性期反应物水平与抗M抗体水平之间存在显著相关性。结核病以IgG抗体为主，伊加抗体较少，IgM抗体最少。急性时相蛋白和总IG水平之间的相关性在IgM类中最明显，与伊加较少，与IgG完全不相关。尽管对照组和患者的蛋白质水平与年龄、性别和体重之间存在一些关联，但这些关联并不足以解释两组之间的差异。与没有寄生虫证据的患者相比，患有肠道蠕虫病的患者（而不是对照组）的总IgM水平往往更高。一般来说，蛋白质水平与疾病的临床和放射学特征关系不大，除抗分枝杆菌抗体外，没有诊断价值。蛋白质水平与疾病程度无关，与红细胞沉降率和白细胞计数相关性更好。转铁蛋白水平往往是较高的慢性疾病，并表现出与直径的皮肤反应结核菌素在24小时，这也是显着较大的慢性疾病。在血液学结果中，最显著的是疾病中淋巴细胞计数和触珠蛋白水平之间的负相关性，表明这种蛋白可能具有调节作用。
The levels of 8 acute phase reactants (.alpha.1-antitrypsin, .alpha.2-macroglobulin, transferrin, .alpha.1-acid glycoprotein, C-reactive protein, ceruloplasmin, haptoglobin and the 3rd component of complement [C3]) and IgG, IgM and IgA were assayed, by laser nephelometry, in sera from 107 East Javanese patients with smear-positive pulmonary tuberculosis and 144 healthy subjects. These levels were correlated with clinical, hematologic and radiologic features, the levels of antibody to Mycobacterium tuberculosis and the diameters of the tuberculin skin test read at various times. Levels of all acute phase reactants increased significantly in tuberculosis except for that of transferrin which was lowered. The correlations between the various acute phase reactants in health and disease were calculated. In general, the correlations were lower in disease than in health, except for C3 and a greatly increased correlation between the levels of .alpha.1-antitrypsin and ceruloplasmin. There was a significant correlation between levels of some of the acute phase reactants and those of antibodies to M. tuberculosis, mainly with IgG, less with IgA and least with IgM antibodies. Correlations between acute phase protein and total Ig levels were most evident in the IgM class, less with IgA and not at all with IgG. Although there were some associations between protein levels and age, sex and weight of controls and patients, these were not great enough to account for the differences between the 2 groups. There was a tendency for patients, but not controls, with intestinal helminthiasis to have higher levels of total IgM than those without evidence of parasites. In general, the levels of proteins bore very little relation to the clinical and radiologic features of disease and were, with the exception of the antimycobacterial antibodies, of no diagnostic value. Protein levels were not associated with the extent of disease; better correlations were found with the erythrocyte sedimentation rate and leukocyte count. Transferrin levels tended to be higher in those with chronic disease and showed a correlation with the diameters of the dermal reactions to tuberculin at 24 h, which were also significantly larger in chronic disease. Among the hematologic findings, the most significant was a negative correlation between the lymphocyte count and haptoglobin levels in disease, suggesting a possible regulatory role for this protein.