Semiconducting polymer nanotheranostics for NIR-II/Photoacoustic imaging-guided photothermal initiated nitric oxide/photothermal therapy
Semiconducting polymer nanotheranostics for NIR-II/Photoacoustic imaging-guided photothermal initiated nitric oxide/photothermal therapy
复制标题
用于 NIR-II/光声成像引导光热引发一氧化氮/光热治疗的半导体聚合物纳米治疗学
DOI：
10.1016/j.biomaterials.2019.119304
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发表时间：
2019-10-01
期刊：
影响因子：
14
通讯作者：
Fan, Quli
中科院分区：
文献类型：
--
作者：
Li, Jie;Jiang, Rongcui;Fan, Quli
气体递质因其高浓度的细胞毒性而成为人们关注的焦点。对于这种浓度依赖的治疗，如何有效地输送气体，准确地控制气体释放到病变部位，并与其他治疗方法相结合，实现精确的治疗，仍然是一个很大的挑战。在这里，我们实现了单一的近红外(NIR)激光引发的一氧化氮(NO)治疗/光热治疗(PTT)使用半导体聚合物纳米颗粒(SPN，PFTDPP)结合S-亚硝基(NO供体，SNAP)。利用SPN良好的光热转化作用，可以时空控制近红外激光能量转化为热来分解S-亚硫醇。同时，考虑到伴随光热产生的PTT，在单一的近红外激光照射下，我们可以方便而准确地进行双重治疗(无治疗/PTT)。此外，半导体聚合物具有结构可修饰性和光谱可调整性，可以提供第二近红外窗口&光声(NIR II/PA)成像来指导光热引发的NO/光热治疗。PFTDPP显示出高达48%的光热转换效率和良好的双模成像信号(NIR-II/光声)。细胞实验表明，联合光热处理的细胞毒性比单独处理的细胞毒性更显著。由于通过双模式成像(NIR II/PA)在体内精确定位肿瘤，该纳米抗癌药物对肿瘤的抑制率为77%。因此，这种光疗技术为肿瘤药物的有效输送和精确控制释放提供了一种新的设计思想。拓宽了气体变送器联合治疗的应用范围，具有良好的应用前景。
Gasotransmitters with their cytotoxicity in high concentration have become the focus of attention. For such concentration depended therapy, how to effectively deliver gases and precisely control gases release to the lesion as well as combine them with other therapy to achieve precise therapeutics is still a big challenge. Herein, we realize single near-infrared (NIR) laser-initiated nitric oxide (NO) therapy/photothermal therapy (PTT) using semiconducting polymer nanoparticles (SPNs, PFTDPP) combing s-nitrosothiol groups (the NO donor, SNAP). By the good photothermal conversion effect of SPNs, NIR laser energy can be spatio-temporally controlled to convert into heat to decompose s-nitrosothiol. Meanwhile, considering the accompanied PTT produced by photothermal, we can easily and precisely conduct a dual therapy (NO therapy/PTT) under single NIR laser irradiation. Additionally, semiconducting polymer with its structural modifiability and spectral adjustability can provide a second NIR window & photoacoustic (NIR II/PA) imaging for guiding photothermal initiated NO/photothermal therapy. PFTDPP showed a high photothermal conversion efficiency of 48% and good dual-mode imaging signals (NIR-II/photoacoustic). Cellular test illustrated that NO combined photothermal presented more prominent cytotoxicity than any one of them individually. As the tumor pinpointed in vivo by dual-mode imaging (NIR II/PA), this nanotheranostics provided a tumor inhibition of 77%. Consequently, such photo-theranostics produced a new design thought for effectively deliver and precisely controlled release of drugs for oncology. And also, it expanded the application range of gasotransmitters combined therapy that shall have a promising application foreground.