HOMER2 binds MYO18B and enhances its activity to suppress anchorage independent growth
HOMER2 binds MYO18B and enhances its activity to suppress anchorage independent growth
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DOI：
10.1016/j.bbrc.2007.03.060
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发表时间：
2007-05-18
影响因子：
3.1
通讯作者：
Yokota, Jun
中科院分区：
文献类型：
--
作者：
Ajima, Rieko;Kajiya, Keiko;Yokota, Jun
MYO 18 B是一种XVIII类肌球蛋白，克隆为肿瘤抑制基因候选者。为了研究MYO 18 B依赖性肿瘤抑制的机制，通过酵母双杂交筛选寻找MYO 18 B相互作用蛋白。HOMER 2是一种Homer/Ves 1家族蛋白，被鉴定为MYO 18 B的结合伴侣。这些蛋白质共定位于膜突起和应力纤维区域，这些区域被称为富含肌动蛋白的丝状结构。HOMER 2的表达增强MYO 18 B抑制锚定非依赖性生长的能力。这些结果表明HOMER 2和MYO 18 B在肿瘤抑制中协同作用。(c)2007年爱思唯尔公司All rights reserved.
MYO18B is a class XVIII myosin, cloned as a tumor suppressor gene candidate. To investigate the mechanisms of MYO18B-dependent tumor suppression, MYO18B-interacting proteins were searched for by a yeast two-hybrid screen. HOMER2, a Homer/Ves1 family protein, was identified as a binding partner of MYO18B. These proteins co-localized in the regions of membrane protrusion and stress fiber, which are known as ones with filamentous actin-rich structures. Expression of HOMER2 enhanced the ability of MYO18B to suppress anchorage-independent growth. These results indicate that HOMER2 and MYO18B cooperate together in tumor suppression. (c) 2007 Elsevier Inc. All rights reserved.