The prokineticins: a novel pair of regulatory peptides.
The prokineticins: a novel pair of regulatory peptides.
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DOI：
10.1124/mi.6.6.6
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发表时间：
2006-12
影响因子：
--
通讯作者：
Q. Zhou
中科院分区：
文献类型：
--
作者：
Q. Zhou
分泌肽在脑功能和身体其他部位发挥广泛的调节作用。前动力素是一对新发现的调节肽，通过两个高度同源的G蛋白偶联受体传递信号。前动力素具有独特的五个二硫键的结构基序和一个完全保守的N-末端六肽序列，这是生物活性所必需的。前动力素具有多种生物学功能，包括在发育和细胞分化中的作用。受各种转录因子影响的基因网络可能在功能上会聚在作为调节靶点的前动力素上。
Secreted peptides play broad regulatory roles in brain function and elsewhere in the body. Prokineticins are a pair of newly identified regulatory peptides that signal through two highly homologous G protein-coupled receptors. Prokineticins possess a unique structural motif of five disulfide bonds and a completely conserved N-terminal hexapeptide sequence that is essential to biological activity. Diverse biological functions, including roles in development and cell differentiation, have been assigned to the prokineticins. A network of genes, subject to various transcriptional factors, may functionally converge on the prokineticins as regulatory targets.