Interictal cerebral and systemic endothelial dysfunction in patients with migraine: a case-control study
Interictal cerebral and systemic endothelial dysfunction in patients with migraine: a case-control study
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DOI：
10.1136/jnnp-2014-309571
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发表时间：
2015-11-01
影响因子：
11
通讯作者：
Lal, Vivek
中科院分区：
文献类型：
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作者：
Rajan, Roopa;Khurana, Dheeraj;Lal, Vivek
背景：虽然偏头痛患者的全身血管内皮功能未受损害，但偏头痛患者是否存在脑血管内皮功能损害尚不清楚。材料与方法我们对45例偏头痛患者和44例健康志愿者进行了一项前瞻性研究。在头带上安装双侧监测探头，应用经颅多普勒屏气指数(BHI)评价双侧大脑中动脉(MCA)30~60 mm、大脑后动脉(PCA)60~80 mm、基底动脉(BA)80~120 mm的脑血管内皮功能。结果偏头痛患者的MCA、PCA、BA平均血流速度与正常对照组比较无明显差异。PCa组的平均BHI明显低于PCa组(p
Background Although systemic endothelial function is unimpaired in migraine, it is unknown whether cerebral endothelial function impairment exists in migraineurs.Materials and methods We conducted a prospective study to assess endothelial function in migraineurs (n=45) and healthy volunteers (n=44). Cerebral endothelial function was assessed by Breath Holding Index (BHI) on transcranial Doppler in bilateral middle cerebral artery (MCA at 30-60 mm), posterior cerebral artery (PCA at 60-80 mm) and basilar artery (BA at 80-120 mm) using bilateral monitoring probes fixed on headband. Brachial artery flow-mediated dilation (FMD) was used as measure of systemic endothelial function.Results There was no difference in baseline mean velocities of MCA, PCA, BA among migraineurs and controls. Mean BHI was significantly lower in PCA (p