POSTNATAL NEUROGENESIS IN GUINEA-PIG
POSTNATAL NEUROGENESIS IN GUINEA-PIG
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DOI：
10.1038/2141098a0
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发表时间：
1967-01-01
期刊：
影响因子：
64.8
通讯作者：
DAS, GD
中科院分区：
文献类型：
--
作者：
ALTMAN, J;DAS, GD
观察了成年大鼠和性早熟豚鼠在生后神经发生方面的异同。与大鼠不同，豚鼠的小脑皮质在出生时就成熟了，出生后只形成了一小部分颗粒细胞。根据外部颗粒层的溶解时间判断，不同哺乳动物小脑神经发生的持续时间似乎与其运动和相关技能成熟所需的时间相关，也与这些技能复杂程度的物种差异有关。因此，在大鼠中，小脑外颗粒层在出生后3周末消失；在猫中，在2个月末消失；在人中(其特征是在12-20个月时非常缓慢和费力地获得两足运动能力)。因此，豚鼠出生后不久小脑神经发生的停止可能与豚鼠有限的运动能力似乎在出生时就已经发育有关。与小脑皮质不同，在豚鼠的海马齿状回中，假定的神经发生相当明显。除了妊娠期短和出生时大脑普遍不成熟之外，还需要考虑其他因素，以解释海马体颗粒细胞群在出生后招募时间延长的原因。这些后期形成的元素可能控制着行为的某些方面，这些行为在出生后就会成熟或发挥作用。
Similarities and differences in postnatal neurogenesis between the altricial rat and the precocial guinea-pig were observed. The cerebellar cortex in the guinea-pig, unlike that of the rat, is mature at birth and only a small fraction of its granule cell population is formed after birth. The duration of cerebellar neurogenesis in different mammalian species, as judged by the time of dissolution of the external granular layer, seems to be correlated with the period that is necessary for the maturation of their locomotor and related skills and also with species differences in the complexity of these skills. Thus, in the rat, the cerebellar external granular layer disappears at the end of the 3rd week after birth; in the cat at the end of the 2nd month; and in man (who is characterized by a very slowly and laboriously acquired bipedal locomotor capacity by 12-20 months. Accordingly, the cessation of cerebellar neurogenesis soon after the birth in the guinea-pig may be related to the circumstance that the limited locomotor capacity of the guinea-pig seems to be developed at birth. In contrast to the cerebellar cortex, postulated neurogenesis is quite pronounced in the hippocampal dentate gyrus of the guinea-pig. Factors other than short gestation period and general immaturity of the brain at birth need to be involved to account for the prolonged postnatal recruitment of the granule cell population of the hippocampus. Possibly these late-forming elements control some aspect of behavior which matures or becomes functional after birth.