Computational analysis of mechanical stress in colonic diverticulosis.
Computational analysis of mechanical stress in colonic diverticulosis.
复制标题
结肠憩室病机械应力的计算分析。
DOI：
10.1038/s41598-020-63049-w
复制
发表时间：
2020
影响因子：
4.6
通讯作者：
Kassab,GhassanS
中科院分区：
文献类型：
--
作者：
Patel,Bhavesh;Guo,Xiaomei;Noblet,Jillian;Chambers,Sean;Gregersen,Hans;Kassab,GhassanS
憩室病是由于结肠上发育出袋状结构（称为憩室）而引起的。该病的病因学知之甚少，导致缺乏有效的治疗方法。众所周知，机械应力在组织重塑中起着重要作用，但其在憩室病中的作用尚未研究。在这里，我们使用计算力学来研究结肠组织中存在的袋状结构所产生的应力分布的变化。本研究的目的有两个：（1）观察单个包装袋周围的应力分布如何变化，以及（2）评价应力升高与包装袋尺寸的相关性。结果表明，高应力集中在袋颈部周围，其值和传播随袋颈部而不是袋表面积的大小而增加。这些研究结果表明，应力分布可能会改变憩室病和恶性循环可能会发生袋大小增加，由于应力升高，这反过来又提高了应力进一步等显着的管腔压力降低将是必要的，以保持在正常水平的压力，根据我们的研究结果和治疗方法，旨在直接减少压力，而应寻求后。
Diverticulosis results from the development of pouch-like structures, called diverticula, over the colon. The etiology of the disease is poorly understood resulting in a lack of effective treatment approaches. It is well known that mechanical stress plays a major role in tissue remodeling, yet its role in diverticulosis has not been studied. Here, we used computational mechanics to investigate changes in stress distribution engendered over the colon tissue by the presence of a pouch-like structure. The objectives of the study were twofold: (1) observe how stress distribution changes around a single pouch and (2) evaluate how stress elevation correlates with the size of the pouch. Results showed that high stresses are concentrated around the neck of a pouch, and their values and propagation increase with the size of the pouch neck rather than the pouch surface area. These findings suggest that stress distribution may change in diverticulosis and a vicious cycle may occur where pouch size increases due to stress elevation, which in turn elevates stress further and so on. Significant luminal pressure reduction would be necessary to maintain stress at normal level according to our results and therapeutic approaches aimed directly at reducing stress should rather be sought after.