Altered pathogenesis of severe pneumovirus infection in response to combined antiviral and specific immunomodulatory agents
Altered pathogenesis of severe pneumovirus infection in response to combined antiviral and specific immunomodulatory agents
复制标题
DOI：
10.1128/jvi.77.2.1237-1244.2003
复制
发表时间：
2003-01-01
影响因子：
5.4
通讯作者：
Domachowske, JB
中科院分区：
文献类型：
--
作者：
Bonville, CA;Easton, AJ;Domachowske, JB
我们在这里报告的反应与症状的肺炎病毒感染的小鼠联合抗病毒和特异性免疫调节剂。感染小鼠肺炎病毒（一种复制呼吸道合胞病毒（RSV）严重感染体征和症状的天然小鼠病原体）的小鼠，在内源性（基因缺失）或外源性（抗体介导）阻断MIP-1 α促炎信号级联反应的情况下给予抗病毒药利巴韦林时，对病毒有反应。虽然这两种治疗方法单独使用都无效，但它们共同使用可显著减轻症状和病理，其中最令人印象深刻的是发病率和死亡率显著降低。这些发现与病毒复制和持续炎症对严重呼吸道病毒感染发病机制的独特和独立贡献的概念一致，它们为研究RSV感染者的治疗方案提供了动力。
We report here the responses of mice with symptomatic pneumovirus infection to combined antiviral and specific immunomodulatory agents. Mice infected with pneumonia virus of mice, a natural mouse pathogen that replicates the signs and symptoms of severe infection with respiratory syncytial virus (RSV), responded to the antiviral agent ribavirin when it was administered in the setting of endogenous (gene deletion) or exogenous (antibody-mediated) blockade of the MIP-1alpha proinflammatory signaling cascade. Although neither treatment is effective alone, together they offer a dramatic reduction in symptoms and pathology, the most impressive of which is a significant reduction in morbidity and mortality. The findings presented are consistent with the notion of unique and independent contributions of virus replication and ongoing inflammation to the pathogenesis of severe respiratory virus infection, and they provide the impetus for the study of this treatment regimen in RSV-infected humans.