Nucleotides
Nucleotides
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DOI：
10.1016/s0899-9007(98)00075-6
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发表时间：
1998-10-01
期刊：
影响因子：
4.4
通讯作者：
Cosgrove, M
中科院分区：
文献类型：
--
作者：
Cosgrove, M
核苷酸（NT）是普遍存在的细胞内化合物，对细胞功能和代谢至关重要。最近的很多兴趣都集中在 NT 作为母乳非蛋白氮部分的组成部分。婴儿配方奶粉中添加 NT 现已在多个国家推出。 NT 的生物效应已在多个领域得到报道。膳食 NT 已被证明对免疫系统的多个组成部分具有重要影响：它们可以增强肠道对铁的吸收；它们影响脂蛋白和长链多不饱和脂肪酸的代谢；它们可能会改变肠道菌群；在一些实验情况下，它们已被证明对肠粘膜和肝脏具有营养作用。临床研究表明，婴儿配方奶粉中添加 NT 可以降低社会经济条件较差的婴儿腹泻发作的发生率，并促进小于胎龄婴儿的追赶性生长。我们将继续开展进一步的工作，以确定 NT 可能发挥有益作用的其他临床情况。 (C) 爱思唯尔科学公司 1998。
Nucleotides (NT) are ubiquitous intracellular compounds of crucial importance to cellular function and metabolism. Much recent interest has focused on NT as components of the non-protein nitrogen fraction of human milk. NT supplementation of infant formula has now been introduced in several countries. Biological effects of NT have been reported in several fields. Dietary NT have been shown to have important effects on several components of the immune system: they may enhance intestinal absorption of iron; they affect lipoprotein and long-chain polyunsaturated fatty acid metabolism; they may alter intestinal flora; and they have been demonstated to have trophic effects on the intestinal mucose and liver in several experimental situations. Clinical studies have shown NT supplementation of infant formula reduces the incidence of diarrheal episodes among socioeconomically deprived infants, and enhances catch-up growth in infants born small for gestational age. Further work will continue to hy to identify other clinical situations in which NT may have a beneficial role. (C) Elsevier Science Inc. 1998.