Histological growth pattern of and alpha-actinin-4 expression in thyroid cancer.
Histological growth pattern of and alpha-actinin-4 expression in thyroid cancer.
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发表时间：
2014-06
影响因子：
2
通讯作者：
Nobuaki Tanaka;T. Yamashita;Sohei Yamamoto;T. Matsunobu;H. Tsuda;K. Honda;T. Yamada;S. Tamai;A. Shiotani
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作者：
Nobuaki Tanaka;T. Yamashita;Sohei Yamamoto;T. Matsunobu;H. Tsuda;K. Honda;T. Yamada;S. Tamai;A. Shiotani
目的探讨甲状腺癌组织生长模式（HGP）和α-肌动蛋白-4 （ACTN4）表达的临床病理意义。患者与方法根据83例甲状腺癌外周肿瘤边缘轮廓及免疫组织化学检测的ACTN4表达情况，将其分为浸润切缘（IM）组和推切缘（PM）组。分析临床分期与临床病理特征的相关性。结果IM和ACTN4高表达分别在39%和49%的肿瘤患者中出现。较高的临床分期与年龄、较高的T、N因子、术前喉返神经麻痹（pre-RLNP）、IM、预后不良显著相关。IV期患者的预后明显差于I-III期患者。在多变量分析中，年龄较大、rlnp前期和IM与较高的临床分期相关。IM与ACTN4高表达显著相关。结论IM、前rlnp和ACTN4的表达可能是甲状腺癌侵袭性的新指标和预后因素。
AIM To assess the clinicopathological significance of the histological growth pattern (HGP) and α-actinin-4 (ACTN4) expression in thyroid cancer. PATIENTS AND METHODS We classified 83 thyroid cancer cases into infiltrative margin (IM) and pushing margin (PM) groups according to peripheral tumor margin contour and immunohistochemically determined ACTN4 expression. Correlations between clinical stage and clinicopathological characteristics were analyzed. RESULTS IM and high ACTN4 expression were observed in 39% and 49% of cancer cases, respectively. Higher clinical stage was significantly correlated with older age, higher T and N factor, preoperative recurrent laryngeal nerve paralysis (pre-RLNP), IM, and poor prognosis. Patients with stage IV disease had significantly poorer prognosis than those with stages I-III. On multivariate analysis, older age, pre-RLNP, and IM correlated with higher clinical stages. IM was significantly correlated with high ACTN4 expression. CONCLUSION IM, pre-RLNP, and ACTN4 expression could be novel indicators of tumor aggression and prognostic factors of thyroid cancer.