Retrospective seroepidemiology indicated that human enterovirus 71 and coxsackievirus A16 circulated wildly in central and southern China before large-scale outbreaks from 2008.
Retrospective seroepidemiology indicated that human enterovirus 71 and coxsackievirus A16 circulated wildly in central and southern China before large-scale outbreaks from 2008.
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DOI：
10.1186/1743-422x-7-300
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发表时间：
2010-11-04
期刊：
影响因子：
4.8
通讯作者：
Xu W
中科院分区：
文献类型：
--
作者：
Zhu Z;Zhu S;Guo X;Wang J;Wang D;Yan D;Tan X;Tang L;Zhu H;Yang Z;Jiang X;Ji Y;Zhang Y;Xu W
2008年以来，中国发生了大规模的全国手足口病暴发；大多数病例是5岁以下的儿童。本研究旨在了解2008年前中国儿童天然人肠道病毒71型（HEV71）和柯萨奇病毒A16型（CVA16）感染情况。对2005年收集的900例≤5岁儿童的血清样本进行了HEV71和CVA16的回顾性血清流行病学研究。样本采集于中国大陆6个不同地理区域（安徽、广东、湖南、新疆、云南和黑龙江）。900份样本中HEV71阳性288份；总阳性率为32.0%，几何平均滴度（GMT）为1:8.5。广东省（43.7%、1:10.8）、新疆（45.4%、1:11.1）、云南（43.4%、1:12.0）感染率较高，黑龙江省（8.1%、1:9 .9）感染率最低。另一方面，390份样品CVA16阳性；总阳性率为43.4%，GMT为1:9.5。安徽（62.2%,1:16.0）和湖南（61.1%,1:23.1）发病率较高，黑龙江（8.0%,1:6 .6）发病率最低。虽然HEV71和CVA16感染存在地域差异，但6个省均存在较低的中和抗体阳性率和抗体滴度。该报告证实，在2008年大规模暴发之前，HEV71和CVA16已在中国的几个省份广泛传播。这也提示应根据不同地区特点制定控制HEV71和CVA16传播的公共卫生措施。
Large nationwide outbreaks of hand, foot, and mouth disease (HFMD) occurred in China from 2008; most of the cases were in children under 5 years. This study aims to identify the situation of natural human enterovirus 71 (HEV71) and coxsackievirus A16 (CVA16) infections in children before 2008 in China. Retrospective seroepidemiologic studies of HEV71 and CVA16 were performed with 900 serum samples collected from children ≤5 years of age in 2005. The samples were collected from 6 different geographical areas (Anhui, Guangdong, Hunan, Xinjiang, Yunnan, and Heilongjiang provinces) in mainland China. Of the 900 samples, 288 were positive for HEV71; the total positive rate was 32.0% and the geometric mean titer (GMT) was 1:8.5. Guangdong (43.7% and 1:10.8), Xinjiang (45.4% and 1:11.1), and Yunnan (43.4% and 1:12.0) provinces had relatively high rates of infection, while Heilongjiang province (8.1% and 1:4.9) had the lowest rate of infection. On the other hand, 390 samples were positive for CVA16; the total positive rate was 43.4% and the GMT was 1:9.5. Anhui (62.2% and 1:16.0) and Hunan (61.1% and 1:23.1) had relatively high rates, while Heilongjiang (8.0% and 1:4.6) had the lowest rate. Although there is a geographical difference in HEV71 and CVA16 infections, low neutralizing antibody positive rate and titer of both viruses were found in all 6 provinces. This report confirmed that HEV71 and CVA16 had wildly circulated in a couple provinces in China before the large-scale outbreaks from 2008. This finding also suggests that public health measures to control the spread of HEV71 and CVA16 should be devised according to the different regional characteristics.