The effects of continuous application of sunscreen on photoaged skin in Japanese elderly people - the relationship with the usage.
The effects of continuous application of sunscreen on photoaged skin in Japanese elderly people - the relationship with the usage.
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DOI：
10.2147/ccid.s104392
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发表时间：
2016
期刊：
影响因子：
--
通讯作者：
Yamamoto Y
中科院分区：
文献类型：
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作者：
Mizuno M;Kunimoto K;Naru E;Kameyama K;Furukawa F;Yamamoto Y
由于皮肤的光老化是由长期暴露在阳光下引起的，因此经常使用防晒霜可以帮助防止皮肤白皙的人的皮肤光老化。因此，许多国家建议使用防晒霜来预防光老化。然而，在日本的临床研究中很少研究紫外线暴露和光老化之间的关系。此外，几乎没有在日本人中进行长期干预性研究。我们之前进行了一项研究，日本光化性角化病患者被指示持续涂抹防晒霜。结果表明，长期涂抹防晒霜可有效抑制光化性角化病的进展和产生。在本研究中，我们调查了防晒霜对14名日本老年人光老化皮肤的影响。皮肤状况，如水含量，经表皮水分损失，斑点，皱纹和肤色均匀性的数量进行了测量和比较之前和之后的研究。仅在皮肤表面水合作用方面观察到统计学显著差异。在整个研究中，防晒霜的使用量存在很大的个体差异。在18个月内，斑点数量和肤色均匀度的变化与防晒霜的使用量有很好的相关性。这些结果表明，在18个月的非防晒霜应用期间，斑点数量增加，肤色均匀性恶化，并且随着防晒霜使用量的增加，这种皮肤状况得到改善。在本研究中，我们提出了一种抑制光老化症状，如斑点和肤色不均匀，通过应用适量的防晒霜在一个长时间的日本人，类似于高加索人。
Since photoaging of skin is caused by chronic sun exposure, it is well-recognized that regular sunscreen use can help prevent photoaging of skin in fair-skinned people. Therefore, application of sunscreen is recommended for the prevention of photoaging in many countries. However, the relationship between UV exposure and photoaging has rarely been investigated in clinical studies in Japan. In addition, there have been almost no long-term interventional studies in Japanese people. We have previously conducted a study where Japanese actinic keratosis patients were instructed to continuously apply sunscreen. The results indicated that long-term application of sunscreen is effective in suppressing actinic keratosis progression and generation. In the present study, we investigated the effects of sunscreen on photoaged skin in 14 elderly Japanese people. Skin conditions such as water content, transepidermal water loss, the number of spots, wrinkles, and skin color tone uniformity were measured and compared before and after the study. A statistically significant difference was observed only in skin surface hydration. There were large inter-individual differences in amount of sunscreen used throughout the study. The changes in the number of spots and skin color tone uniformity during the 18 months showed good correlation with amount of sunscreen being used. These results suggest an increase in the number of spots and deterioration in skin color tone uniformity in the 18-month non-sunscreen application period, and that such skin conditions improved with increasing use of sunscreen. In this study, we suggested an inhibitory effect on photoaging symptoms such as spots and skin color tone non-uniformity, by application of the appropriate amount of sunscreen over a long period of time in Japanese people, similar to Caucasians.