Contribution of Endogenous Opioids to Gonadal Hormones-Induced Temporomandibular Joint Antinociception
Contribution of Endogenous Opioids to Gonadal Hormones-Induced Temporomandibular Joint Antinociception
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DOI：
10.1037/a0017063
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发表时间：
2009-10-01
影响因子：
1.9
通讯作者：
Tambeli, Claudia Herrera
中科院分区：
文献类型：
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作者：
Fischer, Luana;Arthuri, Mariana T.;Tambeli, Claudia Herrera
作者最近证实，在动情周期的动情前期，血清雌二醇水平较高，在切除卵巢的雌性大鼠中给予雌二醇或孕酮，在切除睾丸的雄性大鼠中给予睾酮，可显著降低福尔马林诱导的颞下颌关节（TMJ）伤害感受。在这项研究中，作者调查的贡献，内源性阿片类药物的抗伤害性作用的性腺激素在TMJ福尔马林试验。阿片受体拮抗剂纳洛酮在三叉神经感觉复合体周围或颞下颌关节区给药。在三叉神经感觉复合体周围给予纳洛酮可阻断内源性雌二醇诱导的动情前期雌性动物和外源性雌二醇诱导的卵巢切除雌性动物的抗伤害性感受作用，但在TMJ区域不阻断。在卵巢切除的女性和睾丸切除的男性中的孕酮的管理引起的抗伤害性作用被阻断的纳洛酮的管理，无论是在周围的三叉神经感觉复合体或在颞下颌关节区域。作者得出结论，中枢和外周阿片机制介导孕酮和睾酮的抗伤害效应，中枢阿片机制介导雌二醇的抗伤害效应。这些研究结果表明，在女性和动物的低性腺激素期间，增强的疼痛感知可能是由内源性阿片活性降低介导的。这一建议有助于解释某些疼痛状况的严重程度，例如女性的颞下颌关节功能障碍比男性更严重，而这些疼痛状况没有激素波动。
The authors have recently demonstrated that the high serum estradiol level during the proestrus phase of the estrous cycle and that the administration of estradiol or progesterone in ovariectomized female and of testosterone in orchiectomized male rats significantly decrease formalin-induced temporomandibular joint (TMJ) nociception. In this study, the authors investigate the contribution of endogenous opioids to this antinociceptive effect of gonadal hormones in the TMJ formalin test. The opioid receptor antagonist naloxone was administrated either in the surrounding of the trigeminal sensory complex or in the TMJ region. The antinociceptive effect induced by endogenous estradiol in proestrus females and by exogenous estradiol in ovariectomized females was blocked by the administration of naloxone in the surrounding of the trigeminal sensory complex, but not in the TMJ region. The antinociceptive effect induced by the administration of progesterone in ovariectomized females and of testosterone in orchiectomized males was blocked by the administration of naloxone either in the surrounding of the trigeminal sensory complex or in the TMJ region. The authors conclude that central and peripheral opioid mechanisms mediate the antinociceptive effect of progesterone and testosterone, and central opioid mechanisms mediate the antinociceptive effect of estradiol. These findings suggest that the enhanced pain perception during low gonadal hormone periods in women and animals may be mediated by a decrease in endogenous opioid activity. This suggestion helps explain the higher severity of some pain conditions, such as temporomandibular dysfunctions in women than in men, that have no hormonal fluctuations.