Endothelial-borne platelet-activating factor and interleukin-8 rapidly immobilize rolling neutrophils
Endothelial-borne platelet-activating factor and interleukin-8 rapidly immobilize rolling neutrophils
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DOI：
10.1152/ajpheart.1997.272.1.h114
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发表时间：
1997-01-01
影响因子：
4.8
通讯作者：
Nash, GB
中科院分区：
文献类型：
--
作者：
Rainger, GE;Fisher, AC;Nash, GB
整合素对激活信号的反应动力学必须是快速的，以确保滚动的中性粒细胞定位在炎症部位。从视频记录中，我们分析了单个中性粒细胞在基于血流的内皮缺氧和复氧体外模型中的粘附。缺氧后，流动的中性粒细胞与人脐静脉内皮细胞P-选择素之间存在大量的滚动相互作用，但90%的相互作用持续到缺氧后。
The kinetics of the response of integrins to activating signal(s) must be rapid to ensure that rolling neutrophils are localized at the sites of inflammation. From video records, we analyzed the adhesion of individual neutrophils in a flow-based in vitro model of endothelial hypoxia and reoxygenation. There were numerous rolling interactions between flowing neutrophils and P-selectin an human umbilical vein endothelial cells after hypoxia, but 90% lasted for