Amygdala Hyperspindling and Seizures Induced by Cocaine
Amygdala Hyperspindling and Seizures Induced by Cocaine
复制标题
可卡因引起的杏仁核超细化和癫痫发作
DOI：
10.1007/978-1-4684-3087-5_16
复制
发表时间：
1977
影响因子：
3.3
通讯作者：
C. Khoury
中科院分区：
文献类型：
--
作者：
E. Ellinwood;M. Kilbey;S. Castellani;C. Khoury
The temporal-lobe-like seizures produced by local anesthetics (deJong and Walts, 1966) have at least two possibly important contributions to human pathological conditions: 1) they may help explain the mechanisms underlying temporal lobe epilepsy and/or psychosis occasionally associated with this condition; 2) they may help elucidate the intervening links between the association of the overactivity of the limbic spindle and limbic discharges, with hyperarousal and hyperactive behaviors noted in animal models of chronic stimulant psychosis (see Ellinwood, 1974a for review). Chronic high-dose amphetamine (25–35 mg/kg) administration, or self-administration, in the cat results in bizarre hyperreactive behavior and associated high voltage limbic spindles that may precede tonic-clonic seizures. Furthermore, in chronic high dose amphetamine-intoxicated animals, specific hyperreactive behaviors (at times the animal appears to be reacting to non-existent stimuli) are often immediately preceded by a high voltage spindle and/or discharge in the amygdala, accumbens, and olfactory tubercle (Ellinwood, 1974a; Ellinwood, Sudilovsky, and Nelson, 1974). Much lower doses of amphetamine (10 mg/kg) when administered concomitantly with disulfiram (a dopamine beta hydroxylase inhibitor blocking norepinephrine [NE] synthesis) for only two to three days produces bizarre hyperreactive behavior with hyperspindling leading to tonicclonic seizures (Ellinwood, Sudilovsky, and Grabowy, 1973).
