Identification of chick and mouse Daam1 and Daam2 genes and their expression patterns in the central nervous system
Identification of chick and mouse Daam1 and Daam2 genes and their expression patterns in the central nervous system
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DOI：
10.1016/j.devbrainres.2004.07.014
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发表时间：
2004-10-15
期刊：
影响因子：
--
通讯作者：
Ogura, T
中科院分区：
文献类型：
--
作者：
Kida, Y;Shiraishi, T;Ogura, T
最近在果蝇中描述了控制平面细胞极性（PCP）途径的基因。尽管已经确定了许多PCP相关基因，但目前尚不清楚无脊椎动物胚胎中发现的相同遗传程序是否也在脊椎动物胚胎中发挥作用，特别是在中枢神经系统发育方面。为了深入了解脊椎动物PCP相关基因所发挥的作用，我们克隆和研究了非洲爪蟾Daam基因的鸡和小鼠同源物的表达模式，这是PCP途径的重要组成部分，参与细胞的会聚延伸运动。在发育中的中枢神经组织中观察到的表达模式表明，脊椎动物Daam基因参与神经元细胞分化和运动的关键步骤。(C)2004 Elsevier B.V保留所有权利。
Genes controlling the planar cell polarity (PCP) pathway have recently been described in Drosophila. Although a number of PCP-related genes were identified, it remains unknown whether the same genetic programs found in invertebrate embryos operate in vertebrate embryos, especially with regard to central nervous system development. To gain insights into the roles played by vertebrate PCP-related genes, we cloned and examined the expression patterns of chick and mouse homologues of the Xenopus Daam gene, an essential component of the PCP pathway and involved in the convergent extension movement of cells. The observed expression patterns in developing central nervous tissues suggested that vertebrate Daam genes were involved in pivotal steps in neuronal cell differentiation and movement. (C) 2004 Elsevier B.V All rights reserved.