PROTECTION BY CANDIDA-ALBICANS OF STAPHYLOCOCCUS-AUREUS IN THE ESTABLISHMENT OF DUAL INFECTION IN MICE
PROTECTION BY CANDIDA-ALBICANS OF STAPHYLOCOCCUS-AUREUS IN THE ESTABLISHMENT OF DUAL INFECTION IN MICE
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DOI：
10.1128/iai.50.3.655-659.1985
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发表时间：
1985-01-01
影响因子：
3.1
通讯作者：
JOHNSON, G
中科院分区：
文献类型：
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作者：
CARLSON, E;JOHNSON, G
白色念珠菌已被证明刺激感染小鼠的一些细菌时，这两种生物体接种在腹腔内（E。卡尔森，感染。Immun. 39：193-197，1983）。皮下和腹腔接种金黄色葡萄球菌和C.在对侧注射白色念珠菌的情况下，在真菌接种部位建立了混合感染，而在细菌注射部位未建立混合感染。组织的组织学评价是否存在C。白色念珠菌和S.金黄色葡萄球菌在腹膜内接种两者后显示出腹腔的肠系膜和网膜中的真菌生长。球菌数量众多，并且总是与真菌相关联，位于真菌生长的内部而不是其外围。得出的结论是，这种生长模式以某种方式保护了细菌，并且是所观察到的细菌感染的广义真菌刺激的基础。除C.白色假丝酵母、星状假丝酵母、热带假丝酵母、近平滑假丝酵母、光滑球拟酵母和热灭活假丝酵母。白色念珠菌也表现出一定的能力，以保护细菌同时注射，虽然C。parapsilosis和T. glabrata在这方面不如其他酵母有效。
Candida albicans has been shown to stimulate infection in mice by a number of bacteria when both organisms are inoculated intraperitoneally (E. Carlson, Infect. Immun. 39:193-197, 1983). When subcutaneous and intraperitoneal inoculations were given with Staphylococcus aureus and C. albicans injected at opposite sites, mixed infection was established at the site of fungal inoculation but not at the site of the bacterial injection. Histopathologic evaluation of tissues for the presence of C. albicans and S. aureus after intraperitoneal inoculation of both showed fungal growth in the mesentery and omentum of the abdominal cavity. Cocci were numerous and always associated with the fungi, located within the fungal growth rather than at its periphery. It was concluded that this growth pattern in some way protected the bacteria and was the basis for the generalized fungal stimulation of the bacterial infections observed. In addition to C. albicans, Candida stellatoidea, Candida tropicalis, Candida parapsilosis, Torulopsis glabrata, and heat-inactivated C. albicans also demonstrated some ability to protect bacteria injected simultaneously, although C. parapsilosis and T. glabrata were less effective than the other yeasts in this respect.