Decline in excision circles requires homeostatic renewal or homeostatic death of naive T cells
Decline in excision circles requires homeostatic renewal or homeostatic death of naive T cells
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DOI：
10.1016/s0022-5193(03)00172-3
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发表时间：
2003-10-07
影响因子：
2
通讯作者：
de Boer, RJ
中科院分区：
文献类型：
--
作者：
Dutilh, BE;de Boer, RJ
当TCR在胸腺中形成时，DNA片段从T细胞前体染色体中被切除。这些TCR重排切除环(TREC)是稳定的，不会在细胞分裂中复制，因此在最近离开胸腺的初始T细胞中最常见。在人的一生中，外周幼稚T细胞的平均TREC含量下降了一个到两个数量级。一般认为，胸腺产生的幼稚T细胞随着年龄的增长而减少，这足以解释TREC含量的下降。在这里，我们证明了胸腺产量的减少是必要的。但这并不足以解释TREC的数据。只有当胸腺输出的减少被动态平衡补偿时，才能解释TREC含量的减少。体内平衡反应可以有两种形式：当初始T细胞总数下降时，可能会增加更新率或延长细胞的平均寿命。(C)2003爱思唯尔有限公司。保留所有权利。
When the TCR is formed in the thymus, fragments of DNA are excised from the T cell progenitor chromosome. These TCR rearrangement excision circles (TRECs) are stable, are not replicated in cell division and are therefore most frequent in naive T cells that have recently left the thymus. During life, the average TREC content of peripheral naive T cells decreases between one and two orders of magnitude in humans. It is generally believed that the age-dependent decrease in the production of naive T cells by the thymus is sufficient to explain the decrease in the TREC content. Here, we demonstrate that this decrease in thymic production is required. but it is not sufficient to explain the TREC data. Only if the decrease in thymic output is compensated by homeostasis can one explain the decrease in the TREC content. The homeostatic response can take two forms: when the total number of naive T cells declines, there could be an increase in the renewal rate or an increase of the average cellular lifespan. (C) 2003 Elsevier Ltd. All rights reserved.