Ovarian fibrosarcomas
Ovarian fibrosarcomas
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DOI：
10.1034/j.1600-0412.2002.810420.x
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发表时间：
2002-04-01
影响因子：
4.3
通讯作者：
Akyürek, C
中科院分区：
文献类型：
--
作者：
Çelyk, Ç;Güngör, S;Akyürek, C
讨论本病例报告描述了卵巢纤维肉瘤，一种不常见的肿瘤类型，但最常见的类型卵巢肉瘤。纤维肉瘤是高度恶性的潜在肿瘤。组织学上，肿瘤细胞密集，梭形细胞排列成人字形或故事状：肿瘤细胞边界不清，胞浆嗜酸性，核深染，核仁突出。存在中度至显着程度的多态性，有丝分裂像的数量范围为4至25/10高倍视野（1-4）。在这种情况下，在质量中显示了超过4个有丝分裂像/10个高倍视野。货车Giesan、PTAH和TRPL染色以及Vimentin、Desmin和S-100免疫染色显示间质组织和纤维肉瘤的诊断。Ki-67和PCNA免疫组化用于富细胞纤维瘤和纤维肉瘤的鉴别诊断。大体上，纤维肉瘤的最大直径为7 - 22 cm，平均值为12.3 cm。纤维肉瘤是一种实体瘤，呈分叶状、软质、白灰色、肉质外观和广泛的坏死和出血区域（2，5）。在这个病例中，肿块直径接近12 <$10 <$10 cm，半固体，伴有出血性囊肿，左侧卵巢轮廓不规则。卵巢纤维肉瘤患者年龄在42 - 73岁之间，平均58岁。主要表现为盆腔疼痛、腹部肿大或腹部肿块（2，3，5）。我们的病人是49岁，并提出了症状与腹痛和质量的意识。
DiscussionThis case report describes an ovarian fibrosarcoma, an unusual type of tumor, but the commonest type of ovary sarcoma. Fibrosarcomas are highly malignant potential neoplasms. Histologically, the neoplasms were densely cellular, with the spindle-shaped cells being arranged in a herringbone or storiform pattern: the tumor cells had indistinct borders, eosinophilic cytoplasm, and hyperchromatic nuclei with prominent nucleoli. There was a moderate to marked degree of pleomorphism, and the number of mitotic figures ranged from four to 25/10 high-power fields (1–4). In this case, more than four mitotic figures/10 high-power fields were demonstrated in the mass. Van Giesan, PTAH and TRPL stainings and Vimentin, Desmin and S-100 immunostainings were performed to demonstrate the mesenchymal tissue and the diagnosis of a fibrosarcoma. KÍ-67 and PCNA immunostaining were used for the differential diagnosis of cell rich fibromas and fibrosarcomas. Macroscopically, fibrosarcomas range in size from 7 to 22cm in the greatest diameter, with a mean value of 12.3 cm. Fibrosarcomas are solid tumors with lobulated, soft, white-gray color, fleshy appearances and wide areas of necrosis and hemorrhage (2, 5). In this case, the mass was nearly 12¿ 10¿ 10 cm in diameter, semisolid with hemorhagic cysts and an irregular contour in the left ovary.A patient’s age with ovarian fibrosarcomas ranges from 42 to 73years with an average of 58years. The principal presenting complaints are pelvic pain, abdominal enlargement or awareness of an abdominal mass (2, 3, 5). Our patient was aged 49 years and presented symptoms with abdominal pain and awareness of a mass.