A regions-of-interest volumetric analysis of mobility limitations in community-dwelling older adults
A regions-of-interest volumetric analysis of mobility limitations in community-dwelling older adults
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DOI：
10.1093/gerona/62.9.1048
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发表时间：
2007-09-01
影响因子：
5.1
通讯作者：
Newman, Anne B.
中科院分区：
文献类型：
--
作者：
Rosano, Caterina;Aizenstein, Howard J.;Newman, Anne B.
背景在社区居住的老年人中，更大的活动障碍与更大的弥漫性脑结构异常负担相关，如更高的白色高信号。本研究探讨了与运动控制、步态和平衡相关的区域的灰质体积之间的关联，以及这种关联是否独立于白色物质高密度的负担。心血管健康研究的327名参与者（78.3 +/- 4.1岁，57%为女性）的随机样本提供了脑磁共振成像（MRI）和移动性数据。一种脑成像自动化方法测量了小脑、基底神经节、前额叶和顶叶皮质的灰质体积。步态速度是在以通常的步速行走15英尺时测量的。站立平衡通过计时串联姿势进行评估。在调整人口统计学、头部大小、心血管危险因素和白色物质高密度0-9级评分之前和之后，测量每个区域的体积与步态速度或平衡之间的关系。较小的左小脑和左前额叶区域与较慢的步态相关，独立于协变量和白色高信号。较小的右侧壳核、右侧后上级顶叶皮质和左右小脑与平衡困难相关，与协变量和白色物质高密度无关。运动控制关键区域的灰质体积较小与步态较慢和平衡较差相关，并且这种相关性似乎与其他弥漫性脑异常（如白色物质高信号）无关。
Background. In community-dwelling older adults, greater mobility impairment is associated with greater burden of diffuse brain Structural abnormalities, such as higher white matter hyperintensities. This study examined the association between gray matter volumes of regions related to motor control, gait, and balance and whether this association is independent of burden of white matter hyperintensities.Methods. A random sample of 327 participants of the Cardiovascular Health Study (78.3 +/- 4.1 years old, 57% women) contributed brain magnetic resonance imaging (MRI) and mobility data. A brain imaging automated method measured gray matter volume in cerebellum, basal ganglia, and prefrontal and parietal cortex in both hemispheres. Gait speed was measured while walking 15 feet at usual pace. Standing balance was assessed by timing tandem stance. Associations between each region's volume and gait speed or balance were measured before and after adjustment for demographics, head size, cardiovascular risk factors, and 0-9 grading scores of white matter hyperintensities.Results. Smaller left cerebellum and left prefrontal regions were associated with slower gait, independently of covariates and of white matter hyperintensities. Smaller right putamen, right posterior superior parietal cortex, and both left and right cerebellum were associated with balance difficulty, independently of covariates and white matter hyperintensities.Conclusions. Smaller gray matter volumes in regions crucial for motor control are associated with slower gait and poorer balance, and the association appears to be independent of other diffuse brain abnormalities such as white matter hyperintensities.