Toward Treating to Target in Psoriatic Arthritis
Toward Treating to Target in Psoriatic Arthritis
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DOI：
10.3899/jrheum.150626
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发表时间：
2015-11-01
影响因子：
3.9
通讯作者：
Gladman, Dafna D.
中科院分区：
文献类型：
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作者：
Gladman, Dafna D.
风湿病学中的“靶向治疗”概念最初是为类风湿性关节炎开发的。一个类似的尝试，以开发这样的方法为脊椎关节炎是不成功的，因为评估工具和治疗的目标还没有开发。在银屑病关节炎（PsA）中，已开发出评估疾病活动性、疾病状态和反应性的复合指数，并可用作靶点。缓解有许多定义，但没有一个被广泛接受。然而，已经定义了最小疾病活动状态。现在有证据表明，达标治疗方法是可行的，使用最小疾病活动状态作为目标，并设计一种严格的控制方法，这是优于标准治疗的上级方法。进一步的工作将确定最佳目标和实现目标的最佳方法。
The concept "treat to target" in rheumatology was first developed for rheumatoid arthritis. A similar attempt to develop such an approach for spondyloarthritis was unsuccessful because the assessment tools and target of therapy had not been developed. In psoriatic arthritis (PsA), composite indices to assess disease activity, disease state, and responsiveness have been developed and can be used as targets. There are a number of definitions for remission, but none are widely accepted. However, a state of minimal disease activity has been defined. There is evidence now that the treat-to-target approach is feasible, using the minimal disease activity state as a target and devising a tight control approach, which is superior to standard of care. Further work will determine the best target and the best approach to reach it.