THE NEUROBIOLOGY OF PAIN AND ITS MODULATION
THE NEUROBIOLOGY OF PAIN AND ITS MODULATION
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DOI：
10.1097/00002508-198906002-00002
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发表时间：
1989-01-01
影响因子：
2.9
通讯作者：
HARGREAVES, KM
中科院分区：
文献类型：
--
作者：
DUBNER, R;HARGREAVES, KM
近年来的研究进展表明，痛觉编码过程中存在特殊的神经通路，这些通路对刺激的强度、质量、持续时间和位置等特征的变化非常敏感。已经确定的是，大脑中有三个主要的阿片肽家族：脑啡肽，啡肽和内啡肽。除了这些类阿片肽，其他神经化学物质如血清素和去甲肾上腺素在组织损伤相关信号的调节中发挥作用。这些研究进展正被用于开发控制急性和慢性疼痛的改进方法。非甾体抗炎药通过降低外周伤害感受器的敏化来抑制有害信号。阿片类药物被施用到脊髓周围的膜中，以提供持久的疼痛缓解。外周作用阿片类药物可能代表了一种新的功能类镇痛药，没有中枢作用阿片类药物的不良副作用。三环抗抑郁药物用于神经性疼痛的治疗，基于它们对中枢神经系统的去甲肾上腺素能和血清素能通路的影响。
Recent research advances indicate that specialized neural pathways are involved in the encoding of pain sensations and that these pathways are sensitive to changes in stimulus features, such as intensity, quality, duration, and location. It has also been established that there are three major families of opioid peptides in the brain: the enkephalins, the dynorphins, and the endorphins. In addition to these opioid peptides, other neurochemicals such as serotonin and norepinephrine play a role in the modulation of signals related to tissue damage. These advances in research are being used to develop improved methods for the control of acute and chronic pain. Nonsteroidal anti-inflammatory drugs suppress noxious signals by reducing the sensitization of peripheral nociceptors. Opioid drugs are administered into the membranes surrounding the spinal cord to provide long-lasting pain relief. Peripherally acting opioid drugs may represent a new functional class of analgesics devoid of the undesirable side effects of centrally acting opioids. Tricyclic antidepressant drugs are used in the treatment of neuropathic pain, based on their effects on noradrenergic and serotoninergic pathways in the central nervous system.