Hypoactive Sexual Desire Disorder in Postmenopausal Women: Quality of Life and Health Burden
Hypoactive Sexual Desire Disorder in Postmenopausal Women: Quality of Life and Health Burden
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DOI：
10.1111/j.1524-4733.2008.00483.x
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发表时间：
2009-07-01
期刊：
影响因子：
4.5
通讯作者：
Thorp, John
中科院分区：
文献类型：
--
作者：
Biddle, Andrea K.;West, Suzanne L.;Thorp, John
目的：探讨性欲减退障碍（HSDD）对健康相关生活质量（HRQOL）的影响。方法：采用随机数字电话调查的方法，对1189名自然绝经或手术绝经的女性进行性功能、人口统计学特征、HRQOL和特殊疾病的调查。HSDD定义为女性性功能（C）量表上< 40，个人痛苦量表（C）上< 60。将健康调查简表（SF-12）的总评分和领域评分以及欧洲生活质量（EQ-5D）指数评分和维度与健康个体和选定慢性病的人群标准进行比较。结果：HSDD与HRQOL显著下降相关，SF-12在心理健康方面的评分差异最大（HSDD：45.4 [标准误1.9] vs.无HSDD：51.0 [0.6]，P < 0.01），活力（HSDD：47.7 [1.3] vs.无HSDD：52.0 [0.7]，P < 0.01），社会功能（HSDD：47.3 [1.4] vs.无HSDD：50.9 [0.7]，P < 0.05）和身体疼痛（HSDD：41.4 [2.2] vs.无HSDD：46.7 [0.9]，P < 0.05）。与非抑郁症组相比，抑郁症组EQ-5D指数低0.08分（抑郁症组：0.76 [0.03] vs.非抑郁症组：0.84 [0.02]，P < 0.05）。在自然绝经的妇女中，HSDD与0.1分的下降相关（HSDD：0.78 [0.03] vs.无HSDD 0.88 [0.01]，P < 0.01）。与HSDD的妇女表现出更多的HRQOL损害比健康人群的规范，但与其他慢性疾病，如糖尿病和背痛的成年人相似。结论：妇女与HSDD表现出实质性损害HRQOL。鉴于美国女性的患病率为6.6%至12.5%，HSDD对生活质量构成了重要负担。
Objectives:To describe the health-related quality of life (HRQOL) implications of hypoactive sexual desire disorder (HSDD) in a national sample of postmenopausal women ages 30-70.Methods:The Nationwide Survey of Female Sexual Health, a random-digit telephone survey of US households, collected information on female sexual function, demographic characteristics, HRQOL, and the presence of specific medical disorders from 1189 naturally or surgically postmenopausal women in stable relationships of >= 3 months duration. HSDD was defined as < 40 on the Profile of Female Sexual Function((C)) scale and < 60 on the Personal Distress Scale((C)). Short Form-12 Health Survey (SF-12) summary and domain scores, and EuroQol (EQ-5D) index score and dimensions were compared with population-based norms for healthy individuals and selected chronic conditions.Results:HSDD was associated with significant HRQOL decrements, with the largest SF-12 score differences in mental health (HSDD: 45.4 [standard error 1.9] vs. no HSDD: 51.0 [0.6], P < 0.01), vitality (HSDD: 47.7 [1.3] vs. no HSDD: 52.0 [0.7], P < 0.01), social function (HSDD: 47.3 [1.4] vs. no HSDD: 50.9 [0.7], P < 0.05), and bodily pain (HSDD: 41.4 [2.2] vs. no HSDD: 46.7 [0.9], P < 0.05). EQ-5D index was 0.08 points lower (HSDD: 0.76 [0.03] vs. no HSDD: 0.84 [0.02], P < 0.05) for those with HSDD compared with those without. HSDD was associated with a 0.1-point decrement in naturally menopausal women (HSDD: 0.78 [0.03] vs. no HSDD 0.88 [0.01], P < 0.01). Women with HSDD showed more HRQOL impairment than healthy population norms but were similar to adults with other chronic conditions such as diabetes and back pain.Conclusions:Women with HSDD showed substantial impairment in HRQOL. Given a prevalence of 6.6% to 12.5% among US women, HSDD represents an important burden on quality of life.