Nutrient sensing, growth and senescence.
Nutrient sensing, growth and senescence.
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DOI：
10.1111/febs.14400
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发表时间：
2018-06
期刊：
影响因子：
--
通讯作者：
Korolchuk VI
中科院分区：
文献类型：
--
作者：
Carroll B;Korolchuk VI
细胞生长由广泛的促有丝分裂信号决定，其幅度和相对贡献在整个发育、分化过程中以组织特异性方式变化。感测和适当响应有丝分裂原变化的能力是控制细胞生长的基础，营养感测途径的响应性降低与人类疾病和衰老广泛相关。细胞衰老是一种重要的肿瘤抑制机制，其特征在于响应于复制耗竭或过度DNA损伤而不可逆地退出细胞周期。尽管衰老细胞不能再分裂，但它们仍然保持代谢活性，并显示出一系列促生长表型，这些表型部分由mTORC 1-自噬信号轴支持。随着我们对控制mTORC 1-自噬活性和细胞生长的基本机制的理解不断扩大，我们能够探索营养感知的变化如何有助于细胞衰老的获得和维持。此外，虽然衰老限制细胞转化的保护作用是明确的，但最近，这些促炎衰老细胞的年龄相关积累已被证明有助于生物体适应性的下降。我们将进一步讨论是否可以针对营养传感途径的失调，以促进衰老细胞死亡，这将对健康老龄化具有重要意义。
Cell growth is dictated by a wide range of mitogenic signals, the amplitude and relative contribution of which vary throughout development, differentiation and in a tissue‐specific manner. The ability to sense and appropriately respond to changes in mitogens is fundamental to control cell growth, and reduced responsiveness of nutrient sensing pathways is widely associated with human disease and ageing. Cellular senescence is an important tumour suppressor mechanism that is characterised by an irreversible exit from the cell cycle in response to replicative exhaustion or excessive DNA damage. Despite the fact that senescent cells can no longer divide, they remain metabolically active and display a range of pro‐growth phenotypes that are supported in part by the mTORC1‐autophagy signalling axis. As our understanding of the basic mechanisms of controlling mTORC1‐autophagy activity and cell growth continues to expand, we are able to explore how changes in nutrient sensing contribute to the acquisition and maintenance of cellular senescence. Furthermore, while the protective effect of senescence to limit cellular transformation is clear, more recently, the age‐related accumulation of these pro‐inflammatory senescent cells has been shown to contribute to a decline in organismal fitness. We will further discuss whether dysregulation of nutrient sensing pathways can be targeted to promote senescent cell death which would have important implications for healthy ageing.
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DOI：
10.1083/jcb.201610113
发表时间：
2017-07-03
期刊：
The Journal of cell biology
影响因子：
--
作者：
Carroll B;Nelson G;Rabanal-Ruiz Y;Kucheryavenko O;Dunhill-Turner NA;Chesterman CC;Zahari Q;Zhang T;Conduit SE;Mitchell CA;Maddocks ODK;Lovat P;von Zglinicki T;Korolchuk VI
通讯作者：
Korolchuk VI
DOI：
10.15252/embj.201592862
发表时间：
2016-04-01
期刊：
The EMBO journal
影响因子：
--
作者：
Correia-Melo C;Marques FD;Anderson R;Hewitt G;Hewitt R;Cole J;Carroll BM;Miwa S;Birch J;Merz A;Rushton MD;Charles M;Jurk D;Tait SW;Czapiewski R;Greaves L;Nelson G;Bohlooly-Y M;Rodriguez-Cuenca S;Vidal-Puig A;Mann D;Saretzki G;Quarato G;Green DR;Adams PD;von Zglinicki T;Korolchuk VI;Passos JF
通讯作者：
Passos JF
影响因子：
64.8
作者：
Di Micco, Raffaella;Fumagalli, Marzia;di Fagagna, Fabrizio d'Adda
通讯作者：
di Fagagna, Fabrizio d'Adda
DOI：
10.1146/annurev-pathol-121808-102144
发表时间：
2010
期刊：
Annual review of pathology
影响因子：
--
作者：
Coppé JP;Desprez PY;Krtolica A;Campisi J
通讯作者：
Campisi J
影响因子：
64.5
作者：
Demetriades C;Doumpas N;Teleman AA
通讯作者：
Teleman AA