The Importance of Identification of the Myocardial‐Specific Isoenzyme of Creatine Phosphokinase (MB Form) in the Diagnosis of Acute Myocardial Infarction
The Importance of Identification of the Myocardial‐Specific Isoenzyme of Creatine Phosphokinase (MB Form) in the Diagnosis of Acute Myocardial Infarction
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肌酸磷酸激酶（MB 型）心肌特异性同工酶鉴定在急性心肌梗死诊断中的重要性
DOI：
10.1161/01.cir.47.2.263
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发表时间：
1973
期刊：
影响因子：
37.8
通讯作者：
A. Wallace
中科院分区：
文献类型：
--
作者：
G. Wagner;C. Roe;L. Limbird;R. Rosati;A. Wallace
对所有在 12 个月期间入住冠心病监护病房并诊断可能患有急性心肌梗死的患者 (376 名) 进行了血浆 CPK 同工酶的连续血浆测定。将结果与其他酶研究和心电图的数据进行比较。尝试确定假阳性 CPK-MB（心肌特异性形式）的发生率。所有总CPK和LDH同工酶均未显示心肌坏死且心电图无QRS波改变的患者均被诊断为“无急性梗死”。还确定了 CPK 同工酶数据假阴性的发生率。所有总 CPK 短暂升高、LDH1 超过 LDH2、并出现新的 QRS 变化的患者被称为“明确的”急性梗塞。 CPK-MB 形式存在于所有 55 个样本中（0% 假阴性）。因此，通过该方法测定CPK同工酶可以为急性心肌梗死提供灵敏且特异的指示。
Serial plasma determinations of the isoenzymes of CPK were performed in all patients (376) admitted to a coronary care unit during a 12-month period with diagnosis of possible acute myocardial infarction. Results were compared with data from other enzyme studies and from the electrocardiogram. An attempt was made to determine the incidence of falsely positive CPK-MB (myocardial-specific form). “No acute infarction” was diagnosed in all patients in whom neither total CPK nor the isoenzymes of LDH indicated myocardial necrosis, and in whom there were no QRS changes on ECG. Incidence of falsely negative CPK isoenzyme data was also determined. All patients, in whom total CPK was transiently elevated, and LDH1 exceeded LDH2, and new QRS changes occurred, were termed “definite” acute infarction. CPK-MB form was present in all 55 of these (0% false negative). Therefore, determination of the isoenzymes of CPK by this method provides both a sensitive and specific indication of acute myocardial infarction.