Lymphomas and high-grade astrocytomas: Comparison of water diffusibility and histologic characteristics
Lymphomas and high-grade astrocytomas: Comparison of water diffusibility and histologic characteristics
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DOI：
10.1148/radiol.2241010637
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发表时间：
2002-07-01
期刊：
影响因子：
19.7
通讯作者：
Provenzale, JM
中科院分区：
文献类型：
--
作者：
Guo, AC;Cummings, TJ;Provenzale, JM
目的：确定淋巴瘤和高级星形细胞瘤内的水扩散是否与细胞结构相关。材料与方法：回顾性分析11例脑淋巴瘤（19个病变）和17例星形细胞瘤（19个病变）的超声平面扩散加权磁共振（MR）图像。在表观扩散系数（ADC）增强图上绘制感兴趣的区域。通过将肿瘤的ADC值除以正常区域的ADC值，并将商表示为比率，将ADC值归一化。我们回顾了11例星形细胞瘤（11个病变）和7例淋巴瘤（7个病变）的组织学样本。通过计算核面积百分比和细胞质面积百分比来测量细胞的质量，并将结果表示为核与细胞质（N/C）比。采用双尾t检验比较两种肿瘤类型的ADC和N/C比值。结果：淋巴瘤的平均ADC比为1.15 (SD, 0.33；平均标准误差[SEMI， 0.10)，高级别星形细胞瘤的ADC比为1.68 (SD, 0.48； SEM, 0.11) (P
PURPOSE: To determine if water diffusivity within lymphomas and high-grade astrocytomas correlates with cellularity.MATERIALS AND METHODS: Echo-planar diffusion-weighted magnetic resonance (MR) images obtained in 11 patients with brain lymphomas (19 lesions) and in 17 patients with astrocytomas (19 lesions) were retrospectively reviewed. Regions of interest were drawn on apparent diffusion coefficient (ADC) maps in enhancing tumor. ADC values were normalized by dividing ADC values of tumors by those of normal-appearing regions and expressing the quotient as a ratio. Histologic samples from 11 patients with astrocytomas (11 lesions) and seven patients with lymphoma (seven lesions) were reviewed. Cellularity was measured by calculating the percentage of nuclear area and the percentage of cytoplasmic area and expressing the results as the nuclear-to-cytoplasmic (N/C) ratio. The ADC and N/C ratios of both tumor types were compared by using a two-tailed t test.RESULTS: Mean ADC ratio of lymphomas was 1.15 (SD, 0.33; standard error of the mean [SEMI, 0.10), and that of high-grade astrocytomas was 1.68 (SD, 0.48; SEM, 0.11) (P