Binge-eating disorder as a distinct familial phenotype in obese individuals
Binge-eating disorder as a distinct familial phenotype in obese individuals
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DOI：
10.1001/archpsyc.63.3.313
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发表时间：
2006-03-01
影响因子：
--
通讯作者：
Pope, HG
中科院分区：
文献类型：
--
作者：
Hudson, JI;Lalonde, JK;Pope, HG
内容：暴饮暴食症（BED）--一种最近才引起科学界关注的综合症--经常见于肥胖者，尤其是那些严重肥胖的人。然而，目前还不清楚BED是否代表一种病因学上不同的肥胖行为表型，或者仅仅是一种非特异性的饮食模式，有时在肥胖individuals.Objective：为了测试是否BED聚集在家庭独立的肥胖，如果是这样，是否家庭因素的BED也独立增加肥胖的风险。设计，患者和设置：2002年10月至2004年7月，在社区环境中对超重或肥胖先证者（n = 150）和非BED先证者（n=150）及其一级亲属（n=888）进行了盲法家庭访谈研究。主要结果测量：BED的终身诊断;当前和最高终身体重指数结果：暴饮暴食症在家庭中的聚集性很强，与肥胖无关（比值比，2.2; 95%置信区间，1.4-3.6; P = 40）比无BED先证者的亲属，即使控制先证者体重指数（比值比，2.5; 95%可信区间，1.4-4.4; P= 0.002）结论：暴饮暴食症是一种家族性疾病，其部分原因与肥胖的其他家族性因素不同。此外，这些BED特异性家族因素可能独立增加肥胖的风险，特别是严重肥胖。因此，有针对性的干预措施能够预防或治疗受这些BED特异性家族因素影响的特征，可以减少肥胖的公共卫生负担。
Context: Binge-eating disorder ( BED) - a syndrome that only recently has attracted scientific attention - is often seen in obese individuals, especially those with severe obesity. However, it remains unclear whether BED represents an etiologically distinct behavioral phenotype of obesity or simply a nonspecific eating pattern sometimes seen in obese individuals.Objective: To test whether BED aggregates in families independently of obesity, and if so, whether familial factors for BED also independently increase the risk of obesity.Design, Patients, and Setting: Blinded family interview study of overweight or obese probands with (n=150) and without (n=150) BED, and their first-degree relatives (n=888) in a community setting evaluated between October 2002 and July 2004.Main Outcome Measures: Lifetime diagnosis of BED; current and highest lifetime body mass index (calculated as the weight in kilograms divided by the square of the height in meters).Results: Binge-eating disorder aggregated strongly in families independently of obesity (odds ratio, 2.2; 95% confidence interval, 1.4-3.6; P = 40) than relatives of probands without BED even when controlling for proband body mass index (odds ratio, 2.5; 95% confidence interval, 1.4-4.4; P=.002).Conclusions: Binge-eating disorder is a familial disorder caused in part by factors distinct from other familial factors for obesity. Furthermore, these BED-specific familial factors may independently increase the risk of obesity, especially severe obesity. It follows that targeted interventions capable of preventing or treating traits influenced by these BED-specific familial factors could reduce the public health burden of obesity.