Inflammation and Conception in a Prospective Time-to-Pregnancy Cohort.
Inflammation and Conception in a Prospective Time-to-Pregnancy Cohort.
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DOI：
10.1097/ede.0000000000001451
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发表时间：
2022-03-01
期刊：
影响因子：
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通讯作者：
Steiner AZ
中科院分区：
文献类型：
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作者：
Jukic AMZ;Weinberg CR;Mumford SL;Steiner AZ
Inflammation may contribute to subfertility but this has not been well-explored in large prospective cohort studies. We conducted a prospective 12-month cohort study of time to pregnancy in North Carolina, the Time to Conceive study (2010–2016). Participants were aged 30–44, without a history of infertility (N=727). We analyzed blood samples with a high sensitivity assay for C-reactive protein (CRP). Women reported their weight, height, and other covariates. We natural log-transformed CRP and examined it 1) linearly, after exploration using restricted cubic splines, and 2) in categories based on American Heart Association criteria. We estimated fecundability ratios (FR) with log-binomial discrete-time-to-pregnancy models. Separate models included an interaction term with body mass index (BMI). The adjusted estimated FR per natural log-unit increase in CRP level was 0.97, (confidence interval [CI]: 0.91, 1.0). The FR(CI) for high CRP (>10 mg/L) compared with low CRP (<1 mg/L) was 0.78 (0.52, 1.2). Compared with normal-weight women with low CRP, women with obesity and high CRP had lower estimated fecundability, but the confidence interval was wide (FR(CI): 0.63 (0.35, 1.1)). There was no pattern in the estimated fecundability across levels of CRP within categories of BMI. There was no evidence of an association between CRP and fecundability either alone or within levels of BMI. Further studies of CRP and fecundability should include higher levels of CRP and additional markers of inflammation.
