The HtrA stress response protease contributes to resistance of Brucella abortus to killing by murine phagocytes
The HtrA stress response protease contributes to resistance of Brucella abortus to killing by murine phagocytes
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DOI：
10.1128/iai.64.11.4838-4841.1996
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发表时间：
1996-11-01
影响因子：
3.1
通讯作者：
Roop, RM
中科院分区：
文献类型：
--
作者：
Elzer, PH;Phillips, RW;Roop, RM
与强毒牛种布氏杆菌2308相比，同基因htrA突变体PHE 1对bg培养的小鼠中性粒细胞和巨噬细胞的杀伤抗性降低，并且在BALB/c小鼠模型中感染的早期阶段显著减弱。这些发现进一步确定了htrA基因产物对B发病机制的贡献。流产感染
Compared with virulent Brucella abortus 2308, the isogenic htrA mutant PHE1 shows decreased resistance to killing bg cultured murine neutrophils and macrophages and significant attenuation during the early stages of infection in the BALB/c mouse model. These findings further define the contributions of the htrA gene product to the pathogenesis of B. abortus infections.