Approved IFCC recommendation on reporting results for blood glucose (abbreviated)
Approved IFCC recommendation on reporting results for blood glucose (abbreviated)
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DOI：
10.1373/clinchem.2005.051979
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发表时间：
2005-09-01
影响因子：
9.3
通讯作者：
Okorodudu, AO
中科院分区：
文献类型：
--
作者：
D'Orazio, P;Burnett, RW;Okorodudu, AO
在目前的临床实践中，血浆和血糖可互换使用，因此存在临床误解的风险。在人体血液中，葡萄糖像水一样分布在红细胞和血浆之间。葡萄糖的重量摩尔浓度（每单位水质量的葡萄糖量）在整个样品中是相同的，但血浆中的浓度更高，因为血浆中的水浓度和葡萄糖浓度高于红细胞中的浓度。用于测量葡萄糖的不同设备可以检测和报告根本不同的量。校准品、血浆和红细胞液中不同的水浓度可以解释部分差异。葡萄糖测量结果取决于样品类型以及方法是否需要样品稀释或在未稀释样品中使用生物传感器。如果结果混淆或不加区别地使用，差异可能超过用于诊断和监测糖尿病的葡萄糖测定的最大允许误差，并且使治疗复杂化。IFCC科学部选择性电极和床旁检测工作组（IFCC-SD，WG-SEPOCT）的目标是就报告结果达成全球共识。本文件建议报告血浆中葡萄糖的浓度（单位为mmol/L），无论样本类型或测量技术如何。使用常数因子1.11将全血浓度转换为相关血浆中的等效浓度。转换将提供协调一致的结果，便于患者的分类和护理，并减少治疗误判。(C)2005年美国临床化学协会。
In current clinical practice, plasma and blood glucose are used interchangeably with a consequent risk of clinical misinterpretation. In human blood, glucose, like water, is distributed between erythrocytes and plasma. The molality of glucose (amount of glucose per unit of water mass) is the same throughout the sample, but the concentration is higher in plasma because the concentration of water and, therefore, glucose is higher in plasma than in erythrocytes. Different devices for the measurement of glucose may detect and report fundamentally different quantities. Different water concentrations in calibrators, plasma, and erythrocyte fluid can explain some of the differences. Results of glucose measurements depend on sample type and on whether methods require sample dilution or use biosensors in undiluted samples. If the results are mixed up or used indiscriminately, the differences may exceed the maximum allowable error of glucose determinations for diagnosing and monitoring diabetes mellitus, and complicate the treatment. The goal of the IFCC Scientific Division Working Group on Selective Electrodes and Point of Care Testing (IFCC-SD, WG-SEPOCT) is to reach a global consensus on reporting results. The document recommends reporting the concentration of glucose in plasma (with the unit mmol/L), irrespective of sample type or measurement technique. A constant factor of 1.11 is used to convert concentration in whole blood to the equivalent concentration in the pertinent plasma. The conversion will provide harmonized results, facilitating the classification and care of patients and leading to fewer therapeutic misjudgments. (C) 2005 American Association for Clinical Chemistry.