No Effect of Dietary Fish oil Supplementation on the Recruitment of Brown and Brite Adipocytes in Mice or Humans Under Thermoneutral Conditions.
No Effect of Dietary Fish oil Supplementation on the Recruitment of Brown and Brite Adipocytes in Mice or Humans Under Thermoneutral Conditions.
复制标题
在中性条件下，膳食鱼油补充剂对小鼠或人类棕色脂肪细胞和棕色脂肪细胞的募集没有影响
DOI：
10.1002/mnfr.202000681
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发表时间：
2020
影响因子：
5.2
通讯作者：
Klingenspor M
中科院分区：
文献类型：
--
作者：
Maurer SF;Dieckmann S;Lund J;Fromme T;Hess AL;Colson C;Kjølbæk L;Astrup A;Gillum MP;Larsen LH;Liebisch G;Amri EZ;Klingenspor M
哺乳动物脂肪器官中的Scope-Brown和Brite脂肪细胞提供不颤抖的产热作用，因此具有将化学能作为热量分散的特殊能力。N3系列的多不饱和脂肪酸(PUFA)富含鱼油，已被反复证明能增强这些细胞的生热能力，从而影响身体脂肪和糖耐量。这些影响在饲养在中温环境中的小鼠身上和在人类饮食干预试验中被仔细观察。方法和结果将小鼠饲养在中温环境中，消除了轻度冷暴露对生热脂肪细胞招募的叠加影响。在两个不同的近交系小鼠品系中补充鱼油既不影响体重轨迹，也不增加棕色和棕色脂肪细胞的募集，在存在和不存在模拟冷暴露对脂肪细胞影响的β3肾上腺素受体激动剂的情况下。与这些发现一致的是，超重或肥胖者补充鱼油未能在皮下脂肪组织中招募生热脂肪细胞。结论因此，作者的数据质疑了n3-PUFA作为基于脂肪细胞的生热和能量平衡调节因子的假设潜力。
ScopeBrown and brite adipocytes within the mammalian adipose organ provide non‐shivering thermogenesis and thus, have an exceptional capacity to dissipate chemical energy as heat. Polyunsaturated fatty acids (PUFA) of the n3‐series, abundant in fish oil, have been repeatedly demonstrated to enhance the recruitment of thermogenic capacity in these cells, consequently affecting body adiposity and glucose tolerance. These effects are scrutinized in mice housed in a thermoneutral environment and in a human dietary intervention trial.Methods and resultsMice are housed in a thermoneutral environment eliminating the superimposing effect of mild cold‐exposure on thermogenic adipocyte recruitment. Dietary fish oil supplementation in two different inbred mouse strains neither affects body mass trajectory nor enhances the recruitment of brown and brite adipocytes, both in the presence and absence of a β3‐adrenoreceptor agonist imitating the effect of cold‐exposure on adipocytes. In line with these findings, dietary fish oil supplementation of persons with overweight or obesity fails to recruit thermogenic adipocytes in subcutaneous adipose tissue.ConclusionThus, the authors' data question the hypothesized potential of n3‐PUFA as modulators of adipocyte‐based thermogenesis and energy balance regulation.
影响因子：
4.5
作者：
Worsch S;Heikenwalder M;Hauner H;Bader BL
通讯作者：
Bader BL