The effects of graded experimental trauma on cerebral blood flow and responsiveness to CO2.
The effects of graded experimental trauma on cerebral blood flow and responsiveness to CO2.
复制标题
分级实验创伤对脑血流量和对 CO2 反应的影响。
DOI：
10.3171/jns.1979.51.1.0018
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发表时间：
1979
影响因子：
4.1
通讯作者：
G. Allen
中科院分区：
文献类型：
--
作者：
M. Saunders;J. Miller;D. Stablein;G. Allen
在 26 只猫中研究了分级机械性脑损伤对脑血管对 CO2 反应性的影响。采用流体波冲击模型来产生固定持续时间和可变幅度的硬膜外创伤。将动物维持在动脉含氧量正常的状态，持续监测颅内和全身动脉压、脑电图和呼气末二氧化碳。创伤后，使用 H2 离子清除技术在 PaCO2 水平范围从 20 至 60 mm Hg 连续测量脑血流量。对照动物（未受伤）的脑血管反应性为 2.7%。在轻度创伤组（0.76至1.90 atm），反应性受损（1.7%），而在重伤组（2.90至4.60 atm）则被废除。轻度损伤不会改变静息血流，而严重损伤则导致脑血管阻力显着下降。颅内和全身动脉压的变化与脑损伤的程度成比例。作者提出，这些发现是脑干血管调节中心的创伤造成的。
The effects of graded mechanical cerebral trauma on cerebrovascular reactivity to CO2 was studied in 26 cats. A fluid-wave percussion model was employed which delivered an epidural trauma of fixed duration and variable amplitude. The animals were maintained at arterial normoxia, with constant monitoring of intracranial and systemic arterial pressures, electroencephalograms, and end-tidal CO2. Following trauma, cerebral blood flow was measured using the H2 ion clearance technique at PaCO2 levels ranging sequentially from 20 to 60 mm Hg. Cerebrovascular reactivity for control animals (uninjured) was 2.7%. In the group with mild trauma (0.76 to 1.90 atm) reactivity was impaired (1.7%), and it was abolished in the severely injured group (2.90 to 4.60 atm). Mild injuries did not alter resting blood flows, while severe trauma resulted in a significant decrease in cerebrovascular resistance. Intracranial and systemic arterial pressures were altered proportionately to the level of cerebral injury. The authors propose that trauma to the brain-stem vasoregulatory centers accounts for these findings.