Extracellular ubiquitin levels are increased in coronary heart disease and associated with the severity of the disease
Extracellular ubiquitin levels are increased in coronary heart disease and associated with the severity of the disease
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冠心病时细胞外泛素水平升高，并与疾病的严重程度相关
DOI：
10.1080/00365513.2020.1728783
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发表时间：
2020-02-19
影响因子：
2.1
通讯作者：
He, Yang
中科院分区：
文献类型：
--
作者：
Ji, Yiqun;Yao, Jialu;He, Yang
目的：探讨冠心病患者血浆细胞外泛素(UB)浓度及其与病情严重程度的关系。方法：检测60例健康人和67例冠心病患者UB和基质细胞衍生因子-1a(SDF-1a)水平。采用Gensini评分系统评价冠状动脉粥样硬化程度。采用Spearman相关分析评价UB与低密度脂蛋白胆固醇(LDL-C)、C反应蛋白(CRP)、肌酸激酶同工酶(CK-MB)、心肌肌钙蛋白I(CTnI)、SDF-1a的相关性。建立受试者-操作特征(ROC)曲线以评估UB的预测价值。结果：冠心病患者血浆Ub水平显著高于正常对照组(P<0.0001)，急性心肌梗死(AMI)患者血浆UB水平明显高于稳定型心绞痛(SAP)和不稳定型心绞痛(UAP)组(P均<0.01)。冠心病组Ub与Gensini评分、CRP、CK-MB、cTnI呈正相关。UB的ROC分析显示，冠心病和急性冠状动脉综合征的曲线下面积分别为0.711(95%CI，0.623~0.799)和0.778(95%CI，0.666~0.890)。冠心病患者血浆SDF-1a水平升高，但与Ub浓度及病情严重程度无明显相关性。结论：CHD患者血浆Ub浓度升高，Ub水平的变化可能反映了CHD的进展。
Aim: This study aimed to evaluate concentration of plasma extracellular ubiquitin (UB) in coronary heart disease (CHD) patients and its correlation with the disease severity. Methods: Levels of UB and stromal cell-derived factor-1a (SDF-1a) were measured in 60 healthy controls and 67 CHD cases. Coronary atherosclerosis was assessed with Gensini scoring system. Spearman correlation was used to evaluate the correlation between UB and low-density lipoprotein cholesterol (LDL-C), C-reactive protein (CRP), creatine kinase-MB (CK-MB), cardiac troponin I (cTnI) or SDF-1a. The receiver-operating characteristic (ROC) curve was established to assess the predictive value of UB. Results: Plasma UB levels were significantly higher in CHD patients than in controls (p < .0001), and the levels in those with acute myocardial infarction (AMI) were higher than stable angina pectoris (SAP) and unstable angina pectoris (UAP) groups (both p < .01). UB was also positively correlated with Gensini score, CRP, CK-MB and cTnI in CHD. ROC analysis of UB showed that the area under the curve (AUC) were 0.711 (95%CI, 0.623-0.799) and 0.778 (95%CI, 0.666-0.890) for CHD and acute coronary syndrome (ACS), respectively. Plasma SDF-1a levels were elevated in CHD patients but showed no significant correlation with UB concentration or the severity of the disease. Conclusion: Plasma UB concentration was increased in CHD and the change of UB levels may reflect the progression of CHD.