Computational time-of-flight diffuse optical tomography
Computational time-of-flight diffuse optical tomography
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DOI：
10.1038/s41566-019-0439-x
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发表时间：
2019-08-01
期刊：
影响因子：
35
通讯作者：
Faccio, Daniele
中科院分区：
文献类型：
--
作者：
Lyons, Ashley;Tonolini, Francesco;Faccio, Daniele
通过强扩散介质的成像仍然是一个突出的挑战，特别是在生物和医学成像中的应用。在这里，我们提出了一种基于单光子飞行时间相机的方法，该方法允许结合空间和全时间光子分布数据的计算处理，对嵌入在超过80个传输平均自由路径的强扩散介质内的对象进行成像。该技术是非接触式的，需要1s的采集时间，因此允许Hz帧速率成像。成像深度对应于几厘米的人体组织，使我们能够执行深部成像作为原理证明。
Imaging through a strongly diffusive medium remains an outstanding challenge, in particular in applications in biological and medical imaging. Here, we propose a method based on a single-photon time-of-flight camera that allows, in combination with computational processing of the spatial and full temporal photon distribution data, imaging of an object embedded inside a strongly diffusive medium over more than 80 transport mean free paths. The technique is contactless and requires "I s acquisition times, thus allowing Hz frame rate imaging. The imaging depth corresponds to several centimetres of human tissue and allows us to perform deep-body imaging as a proof of principle.