Microtubules observed within the cistern of RER in neurons of the aged dog
Microtubules observed within the cistern of RER in neurons of the aged dog
复制标题
在老年狗神经元 RER 池内观察到的微管
DOI：
10.1007/bf00691484
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发表时间：
1978
影响因子：
12.7
通讯作者：
S. Suu
中科院分区：
文献类型：
--
作者：
Y. Suzuki;Y. Atoji;S. Suu
对27只随机选择的1个月至16岁的犬进行光镜和电子显微镜检查。27例中有13例神经元内包涵体。特别是，13例阳性病例中有12例是8岁以上的老年犬。包裹体呈两亲性紫色，H.- E.染色并测量直径为3-42 μm。组织化学上，它们被认为是一种糖蛋白复合物。电镜观察发现，包裹体由粗面内质网聚集池和紧密排列的管状结构组成。单个小管的直径约为24 nm，并有11-13个亚基形成其壁。这些成分与微管非常相似。包涵体的出现有明显的年龄依赖性。
Twenty-seven randomly selected dogs ranging from 1 month to 16 years of age were examined light- and electron microscopically. An intraneuronal inclusion body was found in 13 of 27 cases. In particular, 12 of 13 positive cases were elderly dogs of over 8 years of age. The inclusions showed amphophilic violet color with H.-E. stain and measured 3–42 μm in diameter. Histochemically, they were thought to be a glycoprotein complex. The inclusions were characterized by the electron microscopy and composed of aggregated cistern of RER closely packed with tubular structures. The individual tubules measured about 24 nm in diameter and had 11–13 subunits forming their walls. These constituents were very similar to those of microtubules. The occurrence of the inclusion bodies showed an apparent age-dependency.