Interindividual variation in anxiety response to amphetamine:: Possible role for adenosine A2A receptor gene variants
Interindividual variation in anxiety response to amphetamine:: Possible role for adenosine A2A receptor gene variants
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DOI：
10.1002/ajmg.b.30228
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发表时间：
2005-11-05
影响因子：
2.8
通讯作者：
de Wit, H
中科院分区：
文献类型：
--
作者：
Hohoff, C;McDonald, JM;de Wit, H
安非他明被认为主要通过多巴胺系统产生其刺激作用，但其作用也可能受到其他系统的影响。多巴胺D-1和D-2受体与腺苷A（1）和A（2A）受体以异二聚体的形式存在，调节它们的反应性，表明对苯丙胺的反应也可能依赖于腺苷能功能。因此，我们研究了一个腺苷A，和三个腺苷A2 A受体基因多态性的个体间的相关性。接受安慰剂或d-安非他明（10或20 mg）的99名健康志愿者中安非他明反应的变异性。腺苷受体基因的1976 C/T和2592 C/T-ins多态性与两种剂量下焦虑的增加相关。这与最近的观察结果一致，表明腺苷A（2A）受体基因多态性在焦虑中的作用。(c)2005 Wiley-Liss，Inc.
Amphetamine is thought to produce its stimulant effects mainly via the dopamine system, but its effects may also be influenced by other systems. Dopamine D-1 and D-2 receptors exist as heterodimers with adenosine A(1) and A(2A) receptors, which modulate their responsiveness, suggesting that responses to amphetamine may also depend on adenosinergic function. We therefore studied the relevance of one adenosine A, and three adenosine A2A receptor gene polymorphisms for the interindividual. variability in amphetamine response in 99 healthy volunteers who received placebo or d-amphetamine (10 or 20 mg). The 1976C/T and 2592C/T-ins polymorphisms of the adenosine receptor gene were associated with increases in anxiety at both doses. This is consistent with recent observations indicating a role for adenosine A(2A) receptor gene polymorphisms in anxiety. (c) 2005 Wiley-Liss, Inc.