Quantitation of respiratory motion during 4D-PET/CT acquisition
Quantitation of respiratory motion during 4D-PET/CT acquisition
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DOI：
10.1118/1.1739671
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发表时间：
2004-06-01
期刊：
影响因子：
3.8
通讯作者：
Humm, JL
中科院分区：
文献类型：
--
作者：
Nehmeh, SA;Erdi, YE;Humm, JL
我们报告在4D-PET/CT采集过程中呼吸运动的变异性。通过跟踪放置在腹部的外部标记物来监测五名肺癌患者的呼吸运动。在每个治疗床位置采集整个呼吸周期的CT数据。通过跟踪系统记录X射线管状态，以根据呼吸相位对CT数据进行回顾性分类。每个呼吸周期在10个相等的箱中取样。在门控模式下采集4D-PET数据，其中每个呼吸周期被分成10个500 ms的区间。对于CT和PET采集，患者接收音频提示以调节呼吸。然后根据4D-CT和4D-PET数据的呼吸时相将其关联。然后分析在两种模态会话中采集的呼吸周期和每个相位仓内的平均振幅。4D-CT期间的平均呼吸运动周期在4D-PET会话的18%以内。这将反映每个4D-CT箱的持续时间中高达1.8%的波动。这种小的不确定性使得CT和PET数据之间在相位到相位的基础上具有良好的相关性。4D-CT和4D-PET之间的呼吸轨迹内的平均幅度的比较（基于逐箱）显示了类似于15%的最大偏差。本研究证明了进行4D-PET/CT采集的可行性。在大多数情况下，PET和CT会话之间的呼吸运动是一致的，从而改善了PET图像的衰减校正以及PET和CT图像的配准。另一方面，在两名患者中，他们的呼吸运动中存在增加的部分不规则性，这将阻止准确地关联对应的PET和CT图像。(C)2004年美国医学物理学家协会。
We report on the variability of the respiratory motion during 4D-PET/CT acquisition. The respiratory motion for five lung cancer patients was monitored by tracking external markers placed on the abdomen. CT data were acquired over an entire respiratory cycle at each couch position. The x-ray tube status was recorded by the tracking system, for retrospective sorting of the CT data as a function of respiration phase. Each respiratory cycle was sampled in ten equal bins. 4D-PET data were acquired in gated mode, where each breathing cycle was divided into ten 500 ms bins. For both CT and PET acquisition, patients received audio prompting to regularize breathing. The 4D-CT and 4D-PET data were then correlated according to their respiratory phases. The respiratory periods, and average amplitude within each phase bin, acquired in both modality sessions were then analyzed. The average respiratory motion period during 4D-CT was within 18% from that in the 4D-PET sessions. This would reflect up to 1.8% fluctuation in the duration of each 4D-CT bin. This small uncertainty enabled good correlation between CT and PET data, on a phase-to-phase basis. Comparison of the average-amplitude within the respiration trace, between 4D-CT and 4D-PET, on a bin-by-bin basis show a maximum deviation of similar to 15%. This study has proved the feasibility of performing 4D-PET/CT acquisition. Respiratory motion was in most cases consistent between PET and CT sessions, thereby improving both the attenuation correction of PET images, and co-registration of PET and CT images. On the other hand, in two patients, there was an increased partial irregularity in their breathing motion, which would prevent accurately correlating the corresponding PET and CT images. (C) 2004 American Association of Physicists in Medicine.