The antimicrobial effect of acetic acid-An alternative to common local antiseptics?
The antimicrobial effect of acetic acid-An alternative to common local antiseptics?
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DOI：
10.1016/j.burns.2008.11.009
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发表时间：
2009-08-01
期刊：
影响因子：
2.7
通讯作者：
Oehlbauer, M.
中科院分区：
文献类型：
--
作者：
Ryssel, H.;Kloeters, O.;Oehlbauer, M.
醋酸在医学上广泛用于伤口消毒，特别是作为治疗和预防鼠疫的防腐剂已有 6000 多年的历史。本研究的主要目的是证明低浓度 3% 的乙酸作为局部防腐剂的适用性，特别是用于由普通变形杆菌、鲍曼不动杆菌或铜绿假单胞菌等生物体引起的问题感染的抢救程序。本研究旨在比较乙酸与常见局部防腐剂（如 11% 聚维酮碘）的体外抗菌效果。 (Betaisodona (R))、聚己缩酰胺 0.04% (Lavasept (R))、磺磺酰脲 5% 和葡萄糖酸氯己定 1.5% 西曲溴铵 15% (Hibicet (R))。以前的研究表明乙酸具有杀菌作用，但这些数据非常不一致；为了涵盖烧伤单位的典型细菌谱，测试了以下革兰氏阴性和革兰氏阳性细菌菌株：大肠杆菌、普通假单胞菌、铜绿假单胞菌、鲍曼不动杆菌、粪肠球菌、表皮葡萄球菌、耐甲氧西林金黄色葡萄球菌（MRSA）和β-溶血性葡萄球菌A 组和 B 组链球菌。测试显示乙酸具有出色的杀菌效果，特别是对于有问题的革兰氏阴性菌，如普通假单胞菌、铜绿假单胞菌和鲍曼不动杆菌。即使在 3% 的低浓度下进行测试，乙酸的微生物谱也很宽。与我们目前使用的抗菌溶液相比，它对某些细菌表现出相似的杀菌特性，甚至更好。目前正在进行局部应用乙酸的临床价值的评估。由此可见，3%浓度的乙酸具有良好的杀菌效果，因此似乎适合作为局部防腐剂，但还需要进一步的临床研究。 (C) 2008 Elsevier Ltd 和 ISBI。版权所有。
Acetic acid has been commonly used in medicine for more than 6000 years for the disinfection of wounds and especially as an antiseptic agent in the treatment and prophylaxis of the plague. The main goal of this study was to prove the suitability of acetic acid, in low concentration of 3%, as a local antiseptic agent, especially for use in salvage procedures in problematic infections caused by organisms such as Proteus vulgaris, Acinetobacter baumannii or Pseudomonas aeruginosa.This study was designed to compare the in vitro antimicrobial effect of acetic acid with those of common local antiseptics such as povidone-iodine 11% (Betaisodona (R)), polyhexanide 0.04% (Lavasept (R)), mafenide 5% and chlohexidine gluconate 1.5% cetrimide 15% (Hibicet (R)). Former studies suggest the bactericidal effect of acetic acid, but these data are very heterogeneous; therefore, a standardised in vitro study was conducted.To cover the typical bacterial spectrum of a burn unit, the following Gram-negative and Gram-positive bacterial strains were tested: Escherichia coli, P. vulgaris, P. aeruginosa, A. baumannii, Enterococcus faecalis, Staphylococcus epidermidis, methicillin-resistant Staphylococcus aureus (MRSA) and beta-haemolytic Streptococcus group A and B.The tests showed excellent bactericidal effect of acetic acid, particularly with problematic Gram-negative bacteria such as P. vulgaris, P. aeruginosa and A. baumannii. The microbiological spectrum of acetic acid is wide, even when tested at a low concentration of 3%. In comparison to our currently used antiseptic solutions, it showed similar - in some bacteria, even better - bactericidal properties. An evaluation of the clinical value of topical application of acetic acid is currently underway. It can be concluded that acetic acid in a concentration of 3% has excellent bactericidal effect and, therefore, seems to be suitable as a local antiseptic agent, but further clinical studies are necessary. (C) 2008 Elsevier Ltd and ISBI. All rights reserved.