Amplification of a gene related to mammalian mdr genes in drug-resistant Plasmodium falciparum.
Amplification of a gene related to mammalian mdr genes in drug-resistant Plasmodium falciparum.
复制标题
耐药恶性疟原虫中与哺乳动物多重耐药基因相关的基因的扩增。
DOI：
10.1126/science.2658061
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发表时间：
1989
期刊：
影响因子：
--
通讯作者：
Wirth,DF
中科院分区：
文献类型：
--
作者：
Wilson,CM;Serrano,AE;Wasley,A;Bogenschutz,MP;Shankar,AH;Wirth,DF
疟疾寄生虫恶性疟原虫含有至少两个与哺乳动物多药耐药基因相关的基因，其中至少一个是P.与对药物敏感的菌株相比，恶性疟原虫基因在对多种药物耐药的菌株中以更高的水平表达，并且以更高的拷贝数存在。
The malaria parasitePlasmodium falciparumcontains at least two genes related to the mammalian multiple drug resistance genes, and at least one of theP. falciparumgenes is expressed at a higher level and is present in higher copy number in a strain that is resistant to multiple drugs than in a strain that is sensitive to the drugs.