Comments to the article "Artefacts with ascorbate and other redox-active compounds in cell culture: epigenetic modifications, and cell killing due to hydrogen peroxide generation in cell culture media".
Comments to the article "Artefacts with ascorbate and other redox-active compounds in cell culture: epigenetic modifications, and cell killing due to hydrogen peroxide generation in cell culture media".
复制标题
对“细胞培养中含有抗坏血酸和其他氧化还原活性化合物的人工制品：表观遗传修饰以及细胞培养基中过氧化氢生成导致的细胞杀伤”一文的评论。
DOI：
10.1080/10715762.2018.1524891
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发表时间：
2018
期刊：
影响因子：
--
通讯作者：
Saitoh Y
中科院分区：
文献类型：
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作者：
Hamada H;Shimoda K;Saitoh Y;Doi S;Fujitaka Y;Ono T;Hamada H;Araki M;Saitoh Y
在此之前，我们报道了高剂量抗坏血酸通过过氧化氢和超氧阴离子自由基诱导人舌癌细胞死亡和生长停滞的抗癌作用。最近，特别是在实验条件下过氧化氢的生成，指出了与本文有关的评论和关注。在这篇文章中，我想回答这些评论和关注，并陈述我们对这项研究的看法。
Previously, we reported that high-dose ascorbic acid induced carcinostatic effects through hydrogen peroxide and superoxide anion radical generation-induced cell death and growth arrest in human tongue carcinoma cells. Recently, the comments and concerns related to this article were pointed out regarding especially the hydrogen peroxide generation in the experimental condition. In this article, I would like to reply to these comments and concerns and state our thoughts related to the study.