Mosquito RNAi is the major innate immune pathway controlling arbovirus infection and transmission.
Mosquito RNAi is the major innate immune pathway controlling arbovirus infection and transmission.
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DOI：
10.2217/fmb.11.11
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发表时间：
2011-03
影响因子：
3.1
通讯作者：
Blair CD
中科院分区：
文献类型：
--
作者：
Blair CD
蚊子传播的虫媒病毒在人类中引起严重疾病，这些疾病日益成为公共卫生问题，但虫媒病毒感染在蚊子媒介中引起最小的病理学，允许持续感染和终身病毒传播。蚊子对病毒感染的主要先天免疫反应RNAi与人类免疫反应有很大不同，这种差异可能是两种宿主感染不同结果的基础。了解蚊子的抗病毒免疫反应可能会导致阻断虫媒病毒传播的策略，并大大减少疾病。研究重点是RNAi作为主要的蚊子抗病毒反应，这对全面了解蚊子的先天免疫具有最大的潜力。本文回顾了我们目前对蚊子抗病毒RNAi的了解，并绘制了一些填补知识空白所需的未来方向。
Mosquito-borne arboviruses cause serious diseases in humans that are increasingly becoming public health problems, yet arbovirus infections cause minimal pathology in the mosquito vector, allowing persistent infections and lifelong virus transmission. The principal mosquito innate immune response to virus infections, RNAi, differs substantially from the human immune response and this difference could be the basis for the disparate outcomes of infection in the two hosts. Understanding the mosquito antiviral immune response could lead to strategies for interruption of arbovirus transmission and greatly reduce disease. Research focused on RNAi as the primary mosquito antiviral response has the greatest potential for developing a full understanding of mosquito innate immunity. This article reviews our current knowledge of mosquito antiviral RNAi and charts some of the future directions needed to fill knowledge gaps.